Barratt C L, Cohen J
Department of Zoology & Comparative Physiology, University of Birmingham, U.K.
J Reprod Fertil. 1987 Nov;81(2):377-84. doi: 10.1530/jrf.0.0810377.
By calculating the number of spermatozoa produced by the mouse testis after vasectomy, and actually counting the number of spermatozoa present in the epididymides and vasa deferentia, the number of spermatozoa resorbed at different times was quantified. The contributions of sperm phagocytosis and intraluminal dissolution of spermatozoa (separate sperm heads and tails) in sperm disposal were examined. Sperm resorption was clearly demonstrated, with about 100 X 10(6) spermatozoa and 426 X 10(6) spermatozoa having been resorbed by 6 weeks and 6 months after vasectomy, respectively. A characteristic of the vasectomized tract was the high proportion of degenerating spermatozoa, and small lymphocytes, but very few intraluminal phagocytes were observed. The results suggest that spermatozoa are resorbed after vasectomy and that intraluminal sperm dissolution, rather than phagocytosis, is a prominent mechanism of sperm disposal in the tract of the vasectomized mouse.
通过计算输精管结扎后小鼠睾丸产生的精子数量，并实际计数附睾和输精管中存在的精子数量，对不同时间吸收的精子数量进行了量化。研究了精子吞噬作用和精子在管腔内溶解（分离的精子头部和尾部）在精子处理中的作用。输精管结扎后精子吸收得到了明确证实，分别在输精管结扎后6周和6个月时约有1亿和4.26亿精子被吸收。输精管结扎后的管道特征是退化精子和小淋巴细胞比例很高，但观察到管腔内吞噬细胞很少。结果表明，输精管结扎后精子被吸收，并且管腔内精子溶解而非吞噬作用是输精管结扎小鼠管道中精子处理的主要机制。
