Edwards C, Milligan S R
Department of Physiology, King's College, London, U.K.
J Reprod Fertil. 1987 Nov;81(2):525-32. doi: 10.1530/jrf.0.0810525.
Uterine blood flow was assessed in mice by measuring organ uptake of intravenously injected [14C]butanol. In ovariectomized mice, injection of 100 ng oestradiol-17 beta increased blood flow 5-fold over that of untreated controls. The injection of oestradiol-17 beta in progesterone-treated mice also increased uterine blood flow at the time of maximal sensitivity to a decidual stimulus, but not 4 days later. Absolute values of blood flow increased during development of the decidual cell reaction in proportion to the increase in uterine weight, reaching maximal values 96 h after decidual induction. When progesterone injections were stopped 72 h after decidual induction, a rapid decrease in absolute and relative blood flow values preceded the decrease in uterine weight. This decrease in uterine blood flow occurred within 12 h of removing a subcutaneous implant containing progesterone. These results are consistent with the view that increased uterine blood flow during decidual development may be necessary to support the rapid increase in uterine weight at implantation and the subsequent decrease in both relative and absolute uterine blood flow on withdrawal of progesterone may promote decidual regression in the mouse.
通过测量静脉注射的[14C]丁醇的器官摄取量来评估小鼠的子宫血流量。在去卵巢小鼠中，注射100 ng雌二醇-17β可使血流量比未处理的对照组增加5倍。在对蜕膜刺激具有最大敏感性时，向用孕酮处理过的小鼠注射雌二醇-17β也会增加子宫血流量，但4天后不会。在蜕膜细胞反应发展过程中，血流量的绝对值随着子宫重量的增加而成比例增加，在蜕膜诱导后96小时达到最大值。当在蜕膜诱导后72小时停止注射孕酮时，血流量的绝对值和相对值迅速下降，随后子宫重量下降。子宫血流量的这种下降发生在取出含孕酮的皮下植入物后的12小时内。这些结果与以下观点一致，即蜕膜发育过程中子宫血流量的增加可能是支持着床时子宫重量快速增加所必需的，而在孕酮撤药后子宫血流量的相对值和绝对值随后下降可能会促进小鼠蜕膜退化。
