Milligan S R, Edwards C
Department of Physiology, King's College, Strand, London, UK.
J Reprod Fertil. 1990 Sep;90(1):191-7. doi: 10.1530/jrf.0.0900191.
Changes in the extracellular and blood spaces of the uterus were assessed from the distribution volumes of 51Cr-EDTA and 51Cr-labelled red blood cells during the development and regression of the artificially induced decidual cell reaction in ovariectomized, steroid-treated mice. The normally high values for uterine extracellular space (0.35-0.40 microliter/mg) fell to less than 0.20 microliter/mg in association with decidual growth. Uterine blood space increased from around 0.02 microliter/mg to 0.03-0.05 microliter/mg with decidual development. Induction of decidual regression by removal of s.c. progesterone implants caused a rapid decline in tissue blood volume to reach control values (0.01-0.02 microliter/mg) within 24 h and preceded any reduction in uterine weight. Uterine vascular permeability, as determined from the tissue accumulation of 125I-labelled human serum albumin, fell with a similar time course. Tissue extracellular space returned to the higher control values within 48 h of initiating decidual regression.
在去卵巢、接受类固醇处理的小鼠中，通过51Cr-乙二胺四乙酸（51Cr-EDTA）和51Cr标记的红细胞的分布容积，评估了人工诱导蜕膜细胞反应的发育和消退过程中子宫细胞外间隙和血腔的变化。与蜕膜生长相关的子宫细胞外间隙的正常高值（0.35 - 0.40微升/毫克）降至低于0.20微升/毫克。随着蜕膜发育，子宫血腔从约0.02微升/毫克增加到0.03 - 0.05微升/毫克。通过去除皮下孕酮植入物诱导蜕膜消退，导致组织血容量迅速下降，在24小时内达到对照值（0.01 - 0.02微升/毫克），且早于子宫重量的任何减轻。根据125I标记的人血清白蛋白在组织中的蓄积情况确定的子宫血管通透性，在相似的时间进程中下降。在开始蜕膜消退后的48小时内，组织细胞外间隙恢复到较高的对照值。
