接受人类辅助生殖技术的高龄不孕患者妊娠失败的危险因素
Risk factors of pregnancy failure in elderly infertility patients undergoing human assisted reproductive technology.
作者信息
Peng Shu, Sun Hong, Zheng Jie, Zeng Ni, Peng Fangxin
机构信息
Reproductive Medicine, Maternal and Child Health Hospital of Hubei Province Wuhan, Hubei Province, China.
出版信息
Am J Transl Res. 2021 Jun 15;13(6):7306-7311. eCollection 2021.
OBJECTIVE
To investigate the risk factors of pregnancy failure in elderly infertile patients undergoing human assisted reproductive technology (ART).
METHODS
A total of 565 infertile patients undergoing ART were selected and divided into failed pregnancy group (127 cases) and continued pregnancy group (438 cases). Their clinical data were collected, and the influencing factors of pregnancy failure were assessed and compared by univariate and multivariate analysis.
RESULTS
The success and failure rates of in vitro fertilization-embryo transfer (IVF-ET) in pregnant women were 79.44% and 20.56%, while those of intracytoplasmic sperm injection (ICSI) were 75.96% and 24.04%, respectively. There was no remarkable difference between them (all P>0.05). Women's age, numbers of embryos transferred and previous abortion history in the failed pregnancy group were higher than those in the continued pregnancy group, while the number of high-quality embryos, BMI and endometrial thickness (EMT) on human chorionic gonadotropin (hCG) day in the former were lower (all P<0.05).
CONCLUSION
The risk factors of ART pregnancy failure in elderly infertility patients are related to woman's age, numbers of embryos transferred, previous pregnancy abortion history, numbers of high-quality embryos and EMT on hCG day.
目的
探讨高龄不孕患者接受人类辅助生殖技术（ART）妊娠失败的危险因素。
方法
选取565例行ART的不孕患者，分为妊娠失败组（127例）和继续妊娠组（438例）。收集其临床资料，通过单因素和多因素分析评估并比较妊娠失败的影响因素。
结果
妊娠妇女体外受精-胚胎移植（IVF-ET）的成功率和失败率分别为79.44%和20.56%，卵胞浆内单精子注射（ICSI）的成功率和失败率分别为75.96%和24.04%。两者之间无显著差异（均P>0.05）。妊娠失败组女性年龄、移植胚胎数和既往流产史高于继续妊娠组，而前者人绒毛膜促性腺激素（hCG）日优质胚胎数、体重指数（BMI）和子宫内膜厚度（EMT）低于继续妊娠组（均P<0.05）。
结论
高龄不孕患者ART妊娠失败的危险因素与女性年龄、移植胚胎数、既往妊娠流产史、优质胚胎数及hCG日EMT有关。
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