Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
J Healthc Eng. 2021 Jul 7;2021:4894501. doi: 10.1155/2021/4894501. eCollection 2021.
This study presents and evaluates the mathematical model to estimate the mean and variance of single-lead ECG signals in sleep apnea syndrome. Our objective is to use the volatility property of the ECG signal for modeling. ECG signal is a stochastic signal whose mean and variance are time-varying. So, we propose to decompose this nonstationarity into two additive components; a homoscedastic Autoregressive Integrated Moving Average (ARIMA) and a heteroscedastic time series in terms of Exponential Generalized Autoregressive Conditional Heteroskedasticity (EGARCH), where the former captures the linearity property and the latter the nonlinear characteristics of the ECG signal. First, ECG signals are segmented into one-minute segments. The heteroskedasticity property is then examined through various tests such as the ARCH/GARCH test, kurtosis, skewness, and histograms. Next, the ARIMA model is applied to signals as a linear model and EGARCH as a nonlinear model. The appropriate orders of models are estimated by using the Bayesian Information Criterion (BIC). We assess the effectiveness of our model in terms of mean square error (MSE), root mean square error (RMSE), mean absolute error (MAE), and mean absolute percentage error (MAPE). The data in this article is obtained from the Physionet Apnea-ECG database. Results show that the ARIMA-EGARCH model performs better than other models for modeling both apneic and normal ECG signals in sleep apnea syndrome.
本研究提出并评估了用于估计睡眠呼吸暂停综合征中单导联心电图信号均值和方差的数学模型。我们的目标是利用心电图信号的波动性进行建模。心电图信号是一个均值和方差随时间变化的随机信号。因此,我们建议将这种非平稳性分解为两个附加分量;一个同方差自回归积分移动平均(ARIMA)和一个异方差时间序列,采用指数广义自回归条件异方差(EGARCH)表示,前者捕获心电图信号的线性特征,后者捕获其非线性特征。首先,将心电图信号分段为一分钟一段。然后通过各种检验,如 ARCH/GARCH 检验、峰度、偏度和直方图,检查异方差性。接下来,将 ARIMA 模型应用于信号作为线性模型,EGARCH 模型作为非线性模型。通过贝叶斯信息准则(BIC)估计模型的适当阶数。我们根据均方误差(MSE)、均方根误差(RMSE)、平均绝对误差(MAE)和平均绝对百分比误差(MAPE)评估我们模型的有效性。本文中的数据来自 Physionet Apnea-ECG 数据库。结果表明,ARIMA-EGARCH 模型在对睡眠呼吸暂停综合征中呼吸暂停和正常心电图信号进行建模方面优于其他模型。