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使用单导联心电图信号进行自动睡眠呼吸暂停检测的频谱自相关函数和自回归模型的性能评估

Performance evaluation of the spectral autocorrelation function and autoregressive models for automated sleep apnea detection using single-lead ECG signal.

作者信息

Zarei Asghar, Mohammadzadeh Asl Babak

机构信息

Department of Biomedical Engineering, Tarbiat Modares University, Tehran, Iran.

Department of Biomedical Engineering, Tarbiat Modares University, Tehran, Iran.

出版信息

Comput Methods Programs Biomed. 2020 Oct;195:105626. doi: 10.1016/j.cmpb.2020.105626. Epub 2020 Jun 26.

DOI:10.1016/j.cmpb.2020.105626
PMID:32634646
Abstract

BACKGROUND AND OBJECTIVE

This paper addresses the automated recognition of obstructive sleep apnea (OSA) from the analysis of single-lead ECG signals. This is one of the most important problems that is, critical to the realization of monitoring patients with sleep apnea.

METHODS

In the present study, a novel solution based on autoregressive (AR) modeling of the single-lead ECG, and spectral autocorrelation function as an ECG feature extraction method is presented. The more effective features are opted by sequential forward feature selection (SFFS) technique and fed into the random forest for binary classification between the apnea and normal events.

RESULTS

Experimental results on Apnea-ECG database proved that the introduced algorithm resulted in an accuracy of 93.90% (sensitivity of 92.26% and specificity of 94.92%) in per-segment classification, which outperforms the other cutting-edge automatic OSA recognition techniques. Moreover, the proposed algorithm provided an accuracy of 97.14% (sensitivity of 95.65% and specificity of 100%) in discrimination of apnea patients from the normal subjects, which is comparable to the traditional and existing approaches.

CONCLUSIONS

This study suggests that automatic OSA recognition from single-lead ECG signals is possible, which can be used as an inexpensive and low complexity burden alternative to more conventional methods such as Polysomnography.

摘要

背景与目的

本文通过对单导联心电图信号的分析来探讨阻塞性睡眠呼吸暂停(OSA)的自动识别。这是最重要的问题之一,对于实现睡眠呼吸暂停患者的监测至关重要。

方法

在本研究中,提出了一种基于单导联心电图自回归(AR)建模以及将频谱自相关函数作为心电图特征提取方法的新解决方案。通过顺序前向特征选择(SFFS)技术选择更有效的特征,并将其输入随机森林进行呼吸暂停事件与正常事件之间的二元分类。

结果

在Apnea-ECG数据库上的实验结果证明,所引入的算法在逐段分类中准确率达到93.90%(灵敏度为92.26%,特异性为94.92%),优于其他前沿的自动OSA识别技术。此外,所提出的算法在区分呼吸暂停患者与正常受试者时准确率为97.14%(灵敏度为95.65%,特异性为100%),与传统和现有方法相当。

结论

本研究表明从单导联心电图信号自动识别OSA是可行的,它可以作为一种比多导睡眠图等更传统方法成本更低且复杂度负担更小的替代方法。

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