Wang Lan, Chen Fei, Bai Lin, Bai Lang, Huang Zhixin, Peng Yong
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
Medical Team from West China Hospital of Sichuan University in Hubei General Hospital (East Branch), Wuhan, China.
Cardiol Res Pract. 2021 Jul 8;2021:5537275. doi: 10.1155/2021/5537275. eCollection 2021.
In this study, we investigated the association between the plasma NT-proBNP level at admission and the severity of COVID-19 pneumonia. For this retrospective, single-centre cohort study, we enrolled consecutive patients from February 9 to March 4, 2020, in a COVID-19 ward of Hubei General Hospital (East Branch) in Wuhan, which is a government-assigned centre for COVID-19 treatment. Diagnosis was confirmed by microbiological and radiographic findings following the interim guidance of the World Health Organization (WHO). A total of 91 (92.9%) patients were finally included in this study. The median age of the patients was 61 years (IQR, 47-69), and 39 (43.0%) of them were male. Two cases of death were reported (2.3%). Twenty-three patients (25.3%) had NT-proBNP levels above 300 pg/ml. Higher NT-proBNP levels were associated with worse PSI and CT scores. The natural logarithm of the NT-proBNP level was positively correlated with the PSI and CT scores (PSI score: = 0.396, =0.001; CT score: = 0.440, < 0.001). Patients with NT-proBNP ≥300 pg/ml showed a potential risk for higher mortality than patients with NT-proBNP <300 pg/ml (mortality rate, 8.7% vs. 0%; =0.062). The plasma NT-proBNP level of COVID-19 patients was significantly related to the severity of pneumonia.
在本研究中，我们调查了入院时血浆N末端B型利钠肽原（NT-proBNP）水平与新型冠状病毒肺炎（COVID-19肺炎）严重程度之间的关联。对于这项回顾性单中心队列研究，我们纳入了2020年2月9日至3月4日在武汉湖北综合医院（东院区）COVID-19病房连续收治的患者，该医院是政府指定的COVID-19治疗中心。根据世界卫生组织（WHO）的临时指南，通过微生物学和影像学检查结果确诊。最终共有91例（92.9%）患者纳入本研究。患者的中位年龄为61岁（四分位间距，47 - 69岁），其中39例（43.0%）为男性。报告了2例死亡病例（2.3%）。23例患者（25.3%）的NT-proBNP水平高于300 pg/ml。较高的NT-proBNP水平与较差的肺炎严重指数（PSI）和胸部CT评分相关。NT-proBNP水平的自然对数与PSI和CT评分呈正相关（PSI评分：r = 0.396，P = 0.001；CT评分：r = 0.440，P < 0.001）。NT-proBNP≥300 pg/ml的患者比NT-proBNP < 300 pg/ml的患者显示出更高的死亡风险（死亡率，8.7%对0%；P = 0.062）。COVID-19患者的血浆NT-proBNP水平与肺炎严重程度显著相关。
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