Özcan Gökçen, Gündüz Ahmet Kaan, Mirzayev Ibadulla, Sağlik Ayhan
Ankara University Faculty of Medicine, Ophthalmology Department, Ankara, Turkey.
Harran University Faculty of Medicine, Ophthalmology Department, Şanlıurfa, Turkey.
Case Rep Ophthalmol Med. 2021 Jun 10;2021:6615284. doi: 10.1155/2021/6615284. eCollection 2021.
A 63-year-old Caucasian man with metastatic lung adenocarcinoma undergoing chemotherapy and external radiotherapy was referred for routine eye examination. Although he was asymptomatic, ocular examination revealed a relatively well-circumscribed whitish retinal lesion measuring 0.5 × 0.5 × 0.5 mm located along the inferotemporal vascular arcade in the right eye. Optical coherence tomography (OCT) showed a hyperreflective dome-shaped lesion occupying the inner retinal layers with few hyperreflective dots overlying the retina in the posterior vitreous consistent with tumor cells. Fluorescein angiography revealed early hyperfluorescence and late staining without leakage at the lesion site. A diagnosis of presumed retinal metastasis from lung adenocarcinoma was made. At 2 months follow-up after completion of chemotherapy, the retinal lesion was found to have regressed completely leaving minor irregularities in the inner retinal layers on OCT. To date, there have been only 41 cases of carcinoma metastasis to the retina reported in the literature including the current case. Despite its rarity, retinal metastasis should be considered in the differential diagnosis of a white-yellow retinal mass with/without overlying vitreous cells especially in patients with a history of systemic cancer.
一名63岁患有转移性肺腺癌的白人男性正在接受化疗和体外放疗，前来接受常规眼部检查。尽管他没有症状，但眼部检查发现右眼颞下血管弓处有一个相对边界清晰的白色视网膜病变，大小为0.5×0.5×0.5毫米。光学相干断层扫描（OCT）显示一个高反射的圆顶形病变占据了视网膜内层，后玻璃体中视网膜上方有少量高反射点，与肿瘤细胞一致。荧光素血管造影显示病变部位早期高荧光和晚期染色，无渗漏。诊断为推测的肺腺癌视网膜转移。化疗完成后2个月的随访中，发现视网膜病变已完全消退，OCT显示视网膜内层有轻微不规则。迄今为止，包括本病例在内，文献中仅报道了41例癌转移至视网膜的病例。尽管其罕见，但在鉴别诊断有/无玻璃体细胞覆盖的白黄色视网膜肿块时，尤其是有全身癌症病史的患者，应考虑视网膜转移。
