诺昔硫脲对实验性腹膜炎的影响。
Effect of noxythiolin on experimental peritonitis.
作者信息
Gilmore O J, Houang E T, Reid C, Shaw E J
出版信息
Postgrad Med J. 1978 Jan;54(627):33-5. doi: 10.1136/pgmj.54.627.33.
The intraperitoneal instillation of noxythiolin in the treatment of peritonitis is widespread in clinical practice despite contradictory evidence as to its efficacy. In this light the value of noxythiolin was reappraised by studying its effect in guinea-pigs and mice with induced bacterial peritonitis. Treatment with a 1% solution of noxythiolin reduced the mortality rate of mice by 14% (P less than 0.1). The guinea-pig model proved unreliable giving inconsistent mortality rates throughout. Further studies are required to determine the optimum dose and concentration of noxythiolin while the search for more effective intraperitoneal antiseptics should continue.
尽管关于硝噻唑啉治疗腹膜炎的疗效存在矛盾的证据，但腹腔内滴注硝噻唑啉在临床实践中仍广泛应用。鉴于此，通过研究硝噻唑啉对诱导性细菌性腹膜炎豚鼠和小鼠的作用，对其价值进行了重新评估。用1%硝噻唑啉溶液治疗可使小鼠死亡率降低14%（P<0.1）。豚鼠模型被证明不可靠，因为其死亡率始终不一致。需要进一步研究以确定硝噻唑啉的最佳剂量和浓度，同时应继续寻找更有效的腹腔内防腐剂。
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