Gilmore O J, Reid C
Br J Surg. 1976 Dec;63(12):978-80. doi: 10.1002/bjs.1800631224.
Clinical and experimental studies have suggested that intraperitoneal noxytiolin prevents adhesion formation. A reliable experimental animal model was therefore established and the effect of noxytiolin on adhesion formation was evaluated in a controlled trial using 80 rats. All 40 rats given Ringer solution developed adhesions, whereas in 7 out of 40 given noxytiolin no adhesions were found (P less than 0-02). Noxytiolin reduced both the total and the mean number of adhesions formed (P less than 0-2) and their mean length of attachment (P less than 0-05). The anti-adhesive effect of noxytiolin may be due to its anticoagulant, cytotoxic or antibacterial properties.
临床和实验研究表明，腹腔注射诺氟沙星可防止粘连形成。因此，建立了一个可靠的实验动物模型，并在一项使用80只大鼠的对照试验中评估了诺氟沙星对粘连形成的影响。所有40只给予林格液的大鼠均形成了粘连，而40只给予诺氟沙星的大鼠中有7只未发现粘连（P小于0.02）。诺氟沙星减少了形成的粘连总数和平均数量（P小于0.2）及其平均附着长度（P小于0.05）。诺氟沙星的抗粘连作用可能归因于其抗凝、细胞毒性或抗菌特性。
