Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 1277 Jiefang Avenue, 430022, Hubei Province, China.
Huazhong University of Science and Technology, 1037 Luoyu road, Wuhan, 430074, Hubei Province, China.
Sleep Med. 2022 Oct;98:168-173. doi: 10.1016/j.sleep.2021.05.015. Epub 2021 May 21.
Although sleep disorder is thought as a risk factor for functional bowel disorders, its impact role in adolescents remains unknown and the contribution of different sleep dimensions may deserve further attention. This study aimed to evaluate the relationship between multiple sleep dimensions and functional bowel disorders among Chinese college freshmen.
A cross-sectional survey was conducted in college freshmen from Huazhong University of Science and Technology in Wuhan, China in September 2019 with random cluster sampling method. All participants completed questionnaires about living habits, sleep and digestive symptoms. Diagnosis of irritable bowel syndrome and functional constipation were based on the Rome IV criteria. Univariate and multivariate logistic regression models were applied to assess the association of sleep dimensions with irritable bowel syndrome or functional constipation.
Based on the 3335 individuals who completed the questionnaire, the overall prevalence of irritable bowel syndrome and functional constipation in college freshmen were 2.5% and 1.7%, respectively. Multivariate analysis revealed that compared with individuals reporting good sleep quality, those reporting poor (OR = 7.269, 95%CI: 2.876-18.370) were associated with increased risk of irritable bowel syndrome. Similarly, those reporting fair (OR = 2.068, 95%CI: 1.010-4.236) and poor (OR = 5.664, 95%CI: 1.864-17.205) were associated with increased risk of functional constipation. There was no statistically significant association between other sleep dimensions (sleep duration, sleep timing, or sleep latency) and irritable bowel syndrome or functional constipation.
Self-reported poor sleep quality was a stronger independent predictor of functional bowel disorders than other sleep dimensions among Chinese college freshmen. Future intervention studies should consider the role of sleep quality for the prevention of FBDs in adolescents.
尽管睡眠障碍被认为是功能性肠病的危险因素，但它在青少年中的影响作用尚不清楚，不同的睡眠维度可能值得进一步关注。本研究旨在评估中国大一新生的多种睡眠维度与功能性肠病之间的关系。
2019 年 9 月，采用随机整群抽样方法，在中国武汉华中科技大学对大一新生进行了横断面调查。所有参与者都完成了关于生活习惯、睡眠和消化症状的问卷。肠易激综合征和功能性便秘的诊断均基于罗马 IV 标准。采用单因素和多因素 logistic 回归模型评估睡眠维度与肠易激综合征或功能性便秘的相关性。
基于完成问卷的 3335 人，大学生中肠易激综合征和功能性便秘的总患病率分别为 2.5%和 1.7%。多因素分析显示，与睡眠质量良好者相比，睡眠质量差者患肠易激综合征的风险增加（OR=7.269，95%CI：2.876-18.370）。同样，报告睡眠一般（OR=2.068，95%CI：1.010-4.236）和差（OR=5.664，95%CI：1.864-17.205）的人患功能性便秘的风险也增加。其他睡眠维度（睡眠时间、睡眠时间或睡眠潜伏期）与肠易激综合征或功能性便秘之间无统计学显著关联。
与其他睡眠维度相比，自我报告的睡眠质量差是中国大学生功能性肠病的更强独立预测因子。未来的干预研究应考虑睡眠质量在预防青少年功能性肠病中的作用。
