Yang Shuai, Li Shou-Zhen, Guo Fu-Zheng, Zhou Dong-Xu, Sun Xiao-Feng, Tai Jian-Dong
Department of Ultrasound, The First Hospital of Jilin University, Changchun, China.
Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Changchun, China.
Front Neurol. 2022 Aug 10;13:903273. doi: 10.3389/fneur.2022.903273. eCollection 2022.
Previous studies suggested that unhealthy sleep patterns were closely associated with gastrointestinal diseases, but the impact of unhealthy sleep duration on chronic constipation has not been well studied until now. In this study, we aim to explore the association between sleep duration and constipation among males and females.
We utilized the US National Health and Nutrition Examination Surveys data from 2005 to 2010, and adults (≥20 years old) who completed the sleep and bowel health questionnaires were enrolled in this observational study. Sleep duration was categorized into four groups: very short sleep (<5 h/night), short sleep (5-6 h/night), normal sleep (7-8 h/night), and long sleep (≥9 h/night). Chronic constipation was defined as Bristol Stool Scale Type 1(separate hard lumps, like nuts) or Type 2(sausage-like but lumpy). Controlling demographic, lifestyle, and dietary factors, the logistic regression model in Generalized Linear Model (GLM) function was used to estimate the correlation of sleep duration with constipation among men and women.
Of the 11,785 individuals (51.2% males and 48.8% females), 4.3% of men and 10.2% of women had constipation, respectively. More than half of patients with constipation did not adopt the recommended sleep duration. Compared with normal individuals, male participants with constipation had a higher proportion of shorter sleep duration (41.0 vs. 32.3% in the short sleep group and 6.3 vs. 4.7% in the very short sleep group), and female individuals with constipation had a higher proportion of long sleep duration (12.7 vs. 8.2%). After covariates adjustment, men with short sleep duration (5-6 h/night) correlated with increased odds for constipation (OR:1.54, 95%CI:1.05-2.25), and women with long sleep duration (≥9 h/night) linked to the higher constipation risk (OR:1.58, 95%CI:1.10-2.29). Excessive sleep duration in males or insufficient sleep duration in females was neither linked to increased nor decreased constipation risk.
In this observational study of a nationally representative sample of adults, we demonstrate a differential impact of unhealthy sleep duration on constipation among men and women. Short sleep duration poses a higher risk of constipation in men, and excessive sleep duration correlates with higher constipation risk in women.
先前的研究表明，不健康的睡眠模式与胃肠道疾病密切相关，但不健康的睡眠时间对慢性便秘的影响至今尚未得到充分研究。在本研究中，我们旨在探讨男性和女性睡眠时间与便秘之间的关联。
我们利用了2005年至2010年美国国家健康与营养检查调查的数据，完成睡眠和肠道健康问卷的成年人（≥20岁）被纳入本观察性研究。睡眠时间分为四组：极短睡眠（<5小时/晚）、短睡眠（5-6小时/晚）、正常睡眠（7-8小时/晚）和长睡眠（≥9小时/晚）。慢性便秘定义为布里斯托大便分类法1型（硬块状，如坚果）或2型（香肠状但有结块）。在控制人口统计学、生活方式和饮食因素后，使用广义线性模型（GLM）函数中的逻辑回归模型来估计男性和女性睡眠时间与便秘的相关性。
在11785名个体中（男性占51.2%，女性占即48.8%），男性便秘患病率为4.3%，女性为10.2%。超过一半的便秘患者未采用推荐的睡眠时间。与正常个体相比，便秘男性参与者中睡眠时间较短的比例更高（短睡眠组中分别为41.0%对32.3%，极短睡眠组中为6.3%对4.7%），便秘女性个体中长睡眠时间的比例更高（12.7%对8.2%）。在调整协变量后，睡眠时间短（5-6小时/晚）的男性便秘几率增加（比值比：1.54，95%置信区间：1.05-2.25），睡眠时间长（≥9小时/晚）的女性便秘风险更高（比值比：1.58，95%置信区间：1.10-2.29）。男性睡眠时间过长或女性睡眠时间不足均与便秘风险的增加或降低无关。
在这项对具有全国代表性的成年人样本的观察性研究中，我们证明了不健康的睡眠时间对男性和女性便秘的影响存在差异。睡眠时间短会使男性患便秘的风险更高，而睡眠时间过长与女性便秘风险更高相关。
