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基于共识的新冠后长期后遗症(长新冠)管理建议:区域视角

Consensus based recommendations for the management of post-COVID long-term sequelae (Long COVID): a regional perspective.

作者信息

AlShamrani Majid, Farahat Fayssal, Assiri Abdullah, AlHajjar Sami, Albarrak Ali, AlHashemi Hashem, AlZunitan Mohammed, AlAqeel Meshal, AlYami Sami, Memish Ziad A

机构信息

Infection Prevention and Control Program, King Abdulaziz Medical City, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Ministry of Health, Riyadh, Saudi Arabia.

出版信息

Front Med (Lausanne). 2025 Aug 6;12:1453167. doi: 10.3389/fmed.2025.1453167. eCollection 2025.

DOI:10.3389/fmed.2025.1453167
PMID:40842528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12364900/
Abstract

BACKGROUND AND OBJECTIVE

The coronavirus disease 2019 (COVID-19) pandemic marks the biggest public health emergency of the 21 century. The long-term health issues linked to COVID-19, also known as Long COVID, pose a great challenge to patients and society. This article aims to highlight the current unmet clinical needs and present expert recommendations for region-specific assessment and management of Long COVID.

METHODS

A secondary desk research was performed focusing on global and regional guidelines for the assessment and management of Long COVID. The observations from the desk research form the foundation for the consensus statements. Additionally, an expert panel consisting of 10 consultant physicians from related specialties reviewed these guidelines and literature in advisory board meetings to identify unmet needs, bridge clinical gaps, and develop recommendations for the evaluation and management of Long COVID.

RESULTS

The expert recommendation statements were drafted based on overarching principles for the clinical assessment and management of Long COVID. The overarching principles used a targeted, multidisciplinary approach, and collaboration between multiple specialties of healthcare. The panel also highlighted the value of holistic care for the management of Long COVID.

CONCLUSION

Long COVID is a major public health challenge. These expert recommendations are expected to guide healthcare professionals in their clinical decision-making for the assessment, management, and appropriate rehabilitation of patients with Long COVID.

摘要

背景与目的

2019冠状病毒病(COVID-19)大流行是21世纪最大的突发公共卫生事件。与COVID-19相关的长期健康问题,即“长新冠”,给患者和社会带来了巨大挑战。本文旨在强调当前未满足的临床需求,并针对“长新冠”的区域特异性评估和管理提出专家建议。

方法

进行了二次案头研究,重点关注“长新冠”评估和管理的全球及区域指南。案头研究的观察结果构成了共识声明的基础。此外,一个由10名相关专业顾问医师组成的专家小组在咨询委员会会议上审查了这些指南和文献,以确定未满足的需求、弥合临床差距,并制定“长新冠”评估和管理的建议。

结果

专家推荐声明是基于“长新冠”临床评估和管理的总体原则起草的。总体原则采用了有针对性的多学科方法以及医疗保健多个专业之间的协作。该小组还强调了整体护理对“长新冠”管理的价值。

结论

“长新冠”是一项重大的公共卫生挑战。这些专家建议有望指导医疗保健专业人员在对“长新冠”患者进行评估、管理和适当康复时做出临床决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc5/12364900/d1359b70e3f4/fmed-12-1453167-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc5/12364900/e77e9940ec97/fmed-12-1453167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc5/12364900/d1359b70e3f4/fmed-12-1453167-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc5/12364900/e77e9940ec97/fmed-12-1453167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc5/12364900/d1359b70e3f4/fmed-12-1453167-g002.jpg

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Viruses. 2024 Jul 16;16(7):1142. doi: 10.3390/v16071142.
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Long COVID management: a mini review of current recommendations and underutilized modalities.新冠后综合征的管理:当前建议及未充分利用的治疗方式的小型综述
Front Med (Lausanne). 2024 Jun 14;11:1430444. doi: 10.3389/fmed.2024.1430444. eCollection 2024.
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Br Med Bull. 2023 Sep 12;147(1):6-19. doi: 10.1093/bmb/ldad016.
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A systematic review and meta-analysis of long COVID symptoms.长新冠症状的系统评价和荟萃分析。
Syst Rev. 2023 May 27;12(1):88. doi: 10.1186/s13643-023-02250-0.
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Association of Treatment With Nirmatrelvir and the Risk of Post-COVID-19 Condition.尼马曲韦联合治疗与新冠病毒感染后综合征风险的关联。
JAMA Intern Med. 2023 Jun 1;183(6):554-564. doi: 10.1001/jamainternmed.2023.0743.
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Long COVID: major findings, mechanisms and recommendations.长新冠:主要发现、机制和建议。
Nat Rev Microbiol. 2023 Mar;21(3):133-146. doi: 10.1038/s41579-022-00846-2. Epub 2023 Jan 13.
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Long-COVID Symptoms in Individuals Infected with Different SARS-CoV-2 Variants of Concern: A Systematic Review of the Literature.不同关注的 SARS-CoV-2 变异株感染个体的长新冠症状:文献系统综述。
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