Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.
Chem Soc Rev. 2021 Sep 20;50(18):10346-10402. doi: 10.1039/d0cs00945h.
This review provides insight into the rapidly expanding field of metal-based antifungal agents. In recent decades, the antibacterial resistance crisis has caused reflection on many aspects of public health where weaknesses in our medicinal arsenal may potentially be present - including in the treatment of fungal infections, particularly in the immunocompromised and those with underlying health conditions where mortality rates can exceed 50%. Combination of organic moieties with known antifungal properties and metal ions can lead to increased bioavailability, uptake and efficacy. Development of such organometallic drugs may alleviate pressure on existing antifungal medications. Prodigious antimicrobial moieties such as azoles, Schiff bases, thiosemicarbazones and others reported herein lend themselves easily to the coordination of a host of metal ions, which can vastly improve the biocidal activity of the parent ligand, thereby extending the library of antifungal drugs available to medical professionals for treatment of an increasing incidence of fungal infections. Overall, this review shows the impressive but somewhat unexploited potential of metal-based compounds to treat fungal infections.
这篇综述深入探讨了快速发展的金属基抗真菌剂领域。近几十年来，抗菌耐药性危机引发了人们对公共卫生诸多方面的反思，在这些方面，我们的药物储备可能存在弱点——包括真菌感染的治疗，特别是在免疫功能低下和存在潜在健康问题的人群中，死亡率可超过 50%。将具有已知抗真菌特性的有机部分与金属离子结合可以提高生物利用度、摄取率和疗效。开发这种金属有机药物可能会减轻现有抗真菌药物的压力。本文报道的大量抗菌部分，如唑类、席夫碱、硫代氨基甲脒等，很容易与一系列金属离子配位，从而大大提高母体配体的杀菌活性，从而扩大可用于医疗专业人员治疗日益增加的真菌感染的抗真菌药物库。总的来说，这篇综述展示了金属化合物治疗真菌感染的令人印象深刻但尚未充分利用的潜力。
