Grant R, Condon B, Lawrence A, Hadley D M, Patterson J, Bone I, Teasdale G M
Magnetic Resonance Unit, Southern General Hospital, Glascow, Scotland.
Magn Reson Imaging. 1987;5(6):465-8. doi: 10.1016/0730-725x(87)90380-8.
Accurate measurements of CSF volumes would assist in the diagnosis of several important neurological conditions. Using Magnetic Resonance Imaging (MRI) we have devised a method to measure both total intracranial CSF volume and ventricular volume. This initial study, in normal humans, provides an answer to two longstanding questions: first, do these volumes differ between the sexes; second, do both total and ventricular CSF volumes increase with normal aging? We found that the total cranial CSF volume and skull size of males were significantly greater than those of females, but that there was not a statistically significant difference between the ventricular volumes of the sexes. Total cranial CSF volume increased steeply with age in both sexes but although there was an increase in ventricular volume with age in males, no significant increase with age could be demonstrated in females.
准确测量脑脊液体积将有助于诊断几种重要的神经系统疾病。我们利用磁共振成像（MRI）设计了一种方法来测量颅内脑脊液总体积和脑室体积。这项针对正常人类的初步研究回答了两个长期存在的问题：第一，这些体积在性别之间是否存在差异；第二，脑脊液总体积和脑室体积是否会随着正常衰老而增加？我们发现，男性的颅腔脑脊液总体积和颅骨大小显著大于女性，但两性的脑室体积在统计学上没有显著差异。两性的颅腔脑脊液总体积均随年龄急剧增加，尽管男性的脑室体积随年龄增加，但未发现女性的脑室体积随年龄有显著增加。
