Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Universidad de Sevilla, Seville, Spain.
Center for Research in Molecular Medicine & Chronic Diseases (CIMUS), Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Campus Vida, Santiago de Compostela, Spain; Department of Pharmacology, Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, Spain.
Adv Drug Deliv Rev. 2021 Sep;176:113899. doi: 10.1016/j.addr.2021.113899. Epub 2021 Jul 24.
Biological macromolecule-based therapeutics irrupted in the pharmaceutical scene generating a great hope due to their outstanding specificity and potency. However, given their susceptibility to degradation and limited capacity to overcome biological barriers new delivery technologies had to be developed for them to reach their targets. This review aims at analyzing the historical seminal advances that shaped the development of the protein/peptide delivery field, along with the emerging technologies on the lead of the current landscape. Particularly, focus is made on technologies with a potential for transmucosal systemic delivery of protein/peptide drugs, followed by approaches for the delivery of antigens as new vaccination strategies, and formulations of biological drugs in oncology, with special emphasis on mAbs. Finally, a discussion of the key challenges the field is facing, along with an overview of prospective advances are provided.
基于生物大分子的治疗药物在药物领域中异军突起，由于其出色的特异性和效力，给人们带来了巨大的希望。然而，鉴于它们容易降解和有限的克服生物屏障的能力，必须开发新的递药技术，使它们能够到达靶点。本综述旨在分析形成蛋白质/肽类药物递药领域发展的历史开创性进展，以及当前格局下新兴技术。特别关注具有经粘膜系统递送蛋白质/肽类药物潜力的技术，其次是作为新型疫苗策略的抗原递送方法，以及肿瘤学中的生物药物制剂，特别强调单抗。最后，讨论了该领域面临的关键挑战，并概述了预期的进展。
