Department of Pharmacy, Ram-Eesh Institute of Vocational and Technical Education, Greater Noida-201301, Uttar Pradesh, India.
Department of Materials Engineering, Indian Institute of Science, Bangalore-560012, Karnataka, India.
Anticancer Agents Med Chem. 2022;22(4):694-702. doi: 10.2174/1871520621666210726143553.
Cancer is one of the major reasons for mortality across the globe. Many side-effects are associated with the formulations available in the market, affecting the quality of life of the patients. This has caused the researchers to find an alternative source of medications, such as herbal medicine, showing a promising effect in anticancer treatment; one such source is Pomegranate, which belongs to the family Punicaceae. Punica granatum contains many polyphenols that have antioxidant, antidiabetic, and therapeutic effects in the treatment and management of metabolic and cardiovascular diseases, as well as a favourable effect on anticancer therapy. Polyphenols like punicalin, punicalagin, and ellagic acid are a few of the many compounds responsible for the anticancer activity of pomegranate. Many preparations of pomegranate, such as Pomegranate Juice (PJ), Pomegranate Seed Oil (PSO), Pomegranate peel extract (PoPx), etc. are used in various clinical studies. These polyphenols show anticancer activity by either arresting the cell cycle in the G2/M phase, inducing apoptosis or damaging the DNA of tumor cells. This review explicitly discusses the role and mechanism of bioactives obtained from the pomegranate in the treatment and management of cancer. The chemical structure, properties, and role of pomegranate in the treatment of breast, lung, thyroid, colon, and prostate cancer have been focused on in detail. This review also discusses various targeted drug delivery approaches for tumour treatment as well as patented preparation of pomegranate compounds along with the ongoing clinical trials.
癌症是全球主要的死亡原因之一。市场上现有的制剂会产生许多副作用，影响患者的生活质量。这促使研究人员寻找替代药物来源，如草药，其在癌症治疗中显示出有前景的效果；其中一个来源是石榴，属于石榴科。石榴含有许多具有抗氧化、抗糖尿病作用的多酚，对治疗和管理代谢和心血管疾病以及癌症治疗有积极作用。多酚如安石榴甙、鞣花酸等是石榴具有抗癌活性的几种化合物之一。许多石榴制剂，如石榴汁（PJ）、石榴籽油（PSO）、石榴皮提取物（PoPx）等，都被用于各种临床研究。这些多酚通过将细胞周期阻滞在 G2/M 期、诱导细胞凋亡或破坏肿瘤细胞的 DNA 来发挥抗癌作用。本综述明确讨论了从石榴中获得的生物活性物质在癌症治疗和管理中的作用和机制。详细讨论了石榴在治疗乳腺癌、肺癌、甲状腺癌、结肠癌和前列腺癌中的化学结构、性质和作用。本综述还讨论了各种针对肿瘤治疗的靶向药物输送方法以及石榴化合物的专利制剂和正在进行的临床试验。
