Steele M K
Department of Physiology, University of California, San Francisco.
Neuroendocrinology. 1987 Nov;46(5):401-5. doi: 10.1159/000124852.
Angiotensin II (AII; 1.0 microliter of 10(-10) M) injected bilaterally into the anterior hypothalamus-preoptic area of the brain produced a 100% increase in mean whole blood LH concentrations in ovariectomized rats treated with estradiol and progesterone. Injections of equal volumes and concentrations of the peptide into the third cerebral ventricle or into the posterior hypothalamus did not affect blood LH values. The effects of AII administration into the rostral hypothalamus were dose-related and specific. Equimolar injections of angiotensin I or angiotensin III into this region did not significantly affect blood LH levels. Taken together, these data demonstrate that the anterior hypothalamus-preoptic area, compared to the third ventricle or more caudal brain sites, is particularly sensitive to the specific stimulatory actions of AII on LH release.
向去卵巢并接受雌二醇和孕酮处理的大鼠双侧脑内前下丘脑-视前区注射血管紧张素II（AII；1.0微升10⁻¹⁰ M），可使平均全血促黄体生成素（LH）浓度升高100%。向第三脑室或下丘脑后部注射等体积和浓度的该肽，对血液LH值无影响。向 Rostral 下丘脑注射AII的作用具有剂量相关性且具有特异性。向该区域等摩尔注射血管紧张素I或血管紧张素III对血液LH水平无显著影响。综上所述，这些数据表明，与第三脑室或更靠后的脑区相比，前下丘脑-视前区对AII刺激LH释放的特定作用特别敏感。
