Is combination of immunosuppressive drugs the answer to reduce glucocorticoid burden in patients with lupus nephritis?

作者信息

Chandwar Kunal, Pandya Sapan

机构信息

Department of Clinical Immunology and Rheumatology, King George's Medical University, Lucknow, 226003, Uttar Pradesh, India.

Department of Clinical Immunology and Rheumatology, Sardar Vallabhbhai Patel Institute of Medical Sciences and Research and Smt. NHL Municipal Medical College, Ahmedabad, 380006, Gujarat, India.

出版信息

Clin Rheumatol. 2021 Dec;40(12):5121-5123. doi: 10.1007/s10067-021-05868-4. Epub 2021 Jul 28.

DOI:10.1007/s10067-021-05868-4

PMID:34318360

Abstract

摘要

相似文献

Is combination of immunosuppressive drugs the answer to reduce glucocorticoid burden in patients with lupus nephritis?

Clin Rheumatol. 2021 Dec;40(12):5121-5123. doi: 10.1007/s10067-021-05868-4. Epub 2021 Jul 28.

Treatment of lupus nephritis--a work in progress.狼疮性肾炎的治疗——一项正在进行的工作。

N Engl J Med. 2000 Oct 19;343(16):1182-3. doi: 10.1056/NEJM200010193431610.

Summaries for patients. Multitarget therapy for induction treatment of lupus nephritis.患者摘要。狼疮性肾炎诱导治疗的多靶点疗法。

Ann Intern Med. 2015 Jan 6;162(1):I24. doi: 10.7326/P15-9000.

Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis.

N Engl J Med. 2001 Feb 1;344(5):382-3. doi: 10.1056/NEJM200102013440513.

Combined immunosuppressive treatment (CIST) in lupus nephritis: a multicenter, randomized controlled study.狼疮性肾炎的联合免疫抑制治疗（CIST）：一项多中心、随机对照研究。

Clin Rheumatol. 2019 Apr;38(4):1047-1054. doi: 10.1007/s10067-018-4368-8. Epub 2018 Nov 28.

Induction therapy for active lupus nephritis: mycophenolate mofetil versus cyclophosphamide.活动性狼疮性肾炎的诱导治疗：霉酚酸酯与环磷酰胺的比较

Nat Clin Pract Nephrol. 2006 Jun;2(6):314-5. doi: 10.1038/ncpneph0184.

[Advances in induction therapy drugs of lupus nephritis for children].[儿童狼疮性肾炎诱导治疗药物的研究进展]

Zhonghua Er Ke Za Zhi. 2021 Jan 2;59(1):71-74. doi: 10.3760/cma.j.cn112140-20200629-00673.

Efficacy and safety of enteric-coated mycophenolate sodium in combination with two glucocorticoid regimens for the treatment of active lupus nephritis.霉酚酸钠肠溶片联合两种糖皮质激素方案治疗活动性狼疮肾炎的疗效和安全性。

Lupus. 2011 Dec;20(14):1484-93. doi: 10.1177/0961203311418269. Epub 2011 Oct 5.

Successful treatment of combined proliferative and membranous lupus nephritis using a full corticosteroid-free regimen.采用完全无糖皮质激素方案成功治疗增殖性和膜性狼疮性肾炎合并症。

Ann Rheum Dis. 2014 Feb;73(2):474-5. doi: 10.1136/annrheumdis-2013-204385. Epub 2013 Sep 3.

Repeated pulses of methyl-prednisolone with reduced doses of prednisone improve the outcome of class III, IV and V lupus nephritis: An observational comparative study of the Lupus-Cruces and lupus-Bordeaux cohorts.重复脉冲甲基泼尼松龙联合低剂量泼尼松可改善 III、IV 和 V 型狼疮肾炎的预后：狼疮-克鲁斯和狼疮-波尔多队列的观察性比较研究。

Autoimmun Rev. 2017 Aug;16(8):826-832. doi: 10.1016/j.autrev.2017.05.017. Epub 2017 May 28.

本文引用的文献

Effect of Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab on Remission Induction in ANCA-Associated Vasculitis: A Randomized Clinical Trial.利妥昔单抗联合小剂量与大剂量糖皮质激素治疗抗中性粒细胞胞质抗体相关性血管炎诱导缓解的随机临床试验

JAMA. 2021 Jun 1;325(21):2178-2187. doi: 10.1001/jama.2021.6615.

Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.与安慰剂相比，voclosporin治疗狼疮性肾炎的疗效和安全性（AURORA 1）：一项双盲、随机、多中心、安慰剂对照的3期试验。

Lancet. 2021 May 29;397(10289):2070-2080. doi: 10.1016/S0140-6736(21)00578-X. Epub 2021 May 7.

Avacopan for the Treatment of ANCA-Associated Vasculitis.阿伐考潘治疗抗中性粒细胞胞浆抗体相关性血管炎。

N Engl J Med. 2021 Feb 18;384(7):599-609. doi: 10.1056/NEJMoa2023386.

Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis.两年随机对照试验研究贝利尤单抗治疗狼疮肾炎。

N Engl J Med. 2020 Sep 17;383(12):1117-1128. doi: 10.1056/NEJMoa2001180.

Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis.血浆置换联合糖皮质激素治疗重症 ANCA 相关性血管炎。

N Engl J Med. 2020 Feb 13;382(7):622-631. doi: 10.1056/NEJMoa1803537.

Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids.前瞻性观察性单中心队列研究评估利妥昔单抗联合霉酚酸酯治疗狼疮性肾炎而不使用口服皮质类固醇的疗效。

Ann Rheum Dis. 2013 Aug;72(8):1280-6. doi: 10.1136/annrheumdis-2012-202844. Epub 2013 Jun 5.

Lupus. 2011 Dec;20(14):1484-93. doi: 10.1177/0961203311418269. Epub 2011 Oct 5.

Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide.狼疮性肾炎的免疫抑制治疗：欧洲狼疮性肾炎试验，一项低剂量与高剂量静脉注射环磷酰胺的随机试验。

Arthritis Rheum. 2002 Aug;46(8):2121-31. doi: 10.1002/art.10461.

Effect of treatment on the evolution of renal abnormalities in lupus nephritis.治疗对狼疮性肾炎肾脏异常演变的影响。

N Engl J Med. 1984 Aug 23;311(8):491-5. doi: 10.1056/NEJM198408233110802.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验