Yeetong Patra, Laipiriyakun Aunchalee, Sriprapaporn Jiraporn, Ausavarat Surasawadee
Division of Human Genetics, Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Biomed Rep. 2025 Jul 25;23(4):157. doi: 10.3892/br.2025.2035. eCollection 2025 Oct.
Differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy. This disease includes papillary and follicular thyroid tumors, and accounts for the majority of thyroid cancer cases. Although both genetic and environmental variables contribute to the genesis of DTC, specific genetic variants in the Thai population remain to be fully understood. The present case-control study aimed to investigate six single nucleotide polymorphisms (SNPs) associated with DTC susceptibility that had previously been described in genome-wide association studies; namely, rs944289, rs2439302, rs966423, rs116909374, rs1799782 and rs861539, and assess these within a Thai population. A total of 233 patients with histologically confirmed DTC (84.1% papillary, 12.9% follicular, 2.6% mixed and 0.4% Hürthle cell) and 176 control subjects with no history of thyroid disease were enrolled in the present study. Polymerase chain reaction-restriction fragment length polymorphism was used for genotyping. The results of the present study revealed that the six SNPs were not statistically significant (P<0.05) in the Thai population. Moreover, results of the sex-stratified analysis demonstrated that statistically significant associations were apparent between three SNPs in males; namely, SNPs rs2439302 (CC vs. CG genotype: OR, 3.325; P=0.024), rs966423 (CC vs. CT genotype: OR, 0.263; P=0.024; C vs. T allele: OR, 3.780; P=0.015) and rs1799782 (CC vs. CT genotype: OR, 0.194; P=0.046). Collectively, results of the present study may provide useful insights into the genetic diversity associated with cancer risk within the Thai population and highlight the requirement for sex stratification in genetic investigations of thyroid cancer.
分化型甲状腺癌（DTC）是最常见的内分泌恶性肿瘤。这种疾病包括甲状腺乳头状瘤和滤泡状瘤，占甲状腺癌病例的大多数。尽管遗传和环境因素都对DTC的发生有影响，但泰国人群中的特定基因变异仍有待充分了解。本病例对照研究旨在调查先前在全基因组关联研究中描述的与DTC易感性相关的六个单核苷酸多态性（SNP）；即rs944289、rs2439302、rs966423、rs116909374、rs1799782和rs861539，并在泰国人群中对其进行评估。本研究共纳入233例经组织学确诊的DTC患者（84.1%为乳头状癌，12.9%为滤泡状癌，2.6%为混合型癌，0.4%为许特氏细胞癌）和176名无甲状腺疾病史的对照受试者。采用聚合酶链反应-限制性片段长度多态性方法进行基因分型。本研究结果显示，这六个SNP在泰国人群中无统计学意义（P<0.05）。此外，性别分层分析结果表明，男性中三个SNP之间存在统计学显著关联；即SNP rs2439302（CC与CG基因型：OR，3.325；P=0.024）、rs966423（CC与CT基因型：OR，0.263；P=0.024；C与T等位基因：OR，3.780；P=0.015）和rs1799782（CC与CT基因型：OR，0.194；P=（此处原文有误，应为0.046））。总体而言，本研究结果可能为了解泰国人群中与癌症风险相关的遗传多样性提供有用的见解，并强调在甲状腺癌基因研究中进行性别分层的必要性。
