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NDR/LATS-家族蛋白激酶基因对于拟南芥的胚胎发生是不可或缺的。

NDR/LATS-family protein kinase genes are indispensable for embryogenesis in Arabidopsis.

机构信息

Asian Research Center for Bioresource and Environmental Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Nishitokyo-shi, Japan.

Laboratory of Crop Physiology, Research Faculty of Agriculture, Hokkaido University, Sapporo-shi, Japan.

出版信息

FEBS Open Bio. 2021 Sep;11(9):2600-2606. doi: 10.1002/2211-5463.13257. Epub 2021 Aug 6.

DOI:10.1002/2211-5463.13257
PMID:34320276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8409290/
Abstract

NDR/LATS-family protein kinases are conserved among eukaryotes. These protein kinases in yeast and animals phosphorylate specific targets and regulate the cell cycle. Arabidopsis thaliana has eight NDR/LATS-family protein kinase genes (NDR1-8), of which NDR2, NDR4, and NDR5 are involved in regulating pollen development. However, the functions of the other NDR/LATS-family protein kinase genes in plants are unclear. Here, we show that three putative phosphorylation sites of an Arabidopsis basic leucine zipper transcription factor, VIP1, correspond to NDR/LATS-family protein kinase phosphorylation motifs and that two of these three sites are phosphorylated by NDR2, NDR3, or NDR8 in vitro. Expression of NDR1-8 was detected in various tissues. An NDR4 NDR6 NDR7 NDR8 quadruple mutation caused embryonic lethality These results suggest that different NDR/LATS-family protein kinases in plants have distinct physiological roles.

摘要

NDR/LATS 家族蛋白激酶在真核生物中保守存在。这些蛋白激酶在酵母和动物中可磷酸化特定靶标并调节细胞周期。拟南芥有八个 NDR/LATS 家族蛋白激酶基因（NDR1-8），其中 NDR2、NDR4 和 NDR5 参与调节花粉发育。然而，植物中其他 NDR/LATS 家族蛋白激酶基因的功能尚不清楚。在这里，我们表明拟南芥碱性亮氨酸拉链转录因子 VIP1 的三个假定磷酸化位点对应于 NDR/LATS 家族蛋白激酶的磷酸化基序，并且这三个位点中的两个可被 NDR2、NDR3 或 NDR8 在体外磷酸化。NDR1-8 的表达在各种组织中均有检测到。NDR4NDR6NDR7NDR8 四重突变导致胚胎致死。这些结果表明，植物中不同的 NDR/LATS 家族蛋白激酶具有不同的生理作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af2/8409290/c16d106f0feb/FEB4-11-2600-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af2/8409290/e5dd622df722/FEB4-11-2600-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af2/8409290/4b837bd44786/FEB4-11-2600-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af2/8409290/c16d106f0feb/FEB4-11-2600-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af2/8409290/e5dd622df722/FEB4-11-2600-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af2/8409290/4b837bd44786/FEB4-11-2600-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9af2/8409290/c16d106f0feb/FEB4-11-2600-g003.jpg

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Plant J. 2021 Feb;105(4):1035-1052. doi: 10.1111/tpj.15085. Epub 2020 Dec 11.
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Protein phosphatase 2A regulates the nuclear accumulation of the Arabidopsis bZIP protein VIP1 under hypo-osmotic stress.
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