用 Δ-9-四氢大麻酚对小鼠进行免疫抑制。
Immunosuppression of mice by delta-9-tetrahydrocannabinol.
作者信息
Lefkowitz S S, Klager K, Nemeth D, Pruess M
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Jan;19(1):101-7.
PMID:343205
Abstract
Studies were initiated to determine the effects of delta-9-tetrahydrocannibinol (THC) on the production of indirect IgG plaque-forming and rosette-forming cells in mice. BDF1 mice were immunized with sheep erythrocytes followed by multiple injections of 10, 25 or 40 mg/kg THC. Results indicated that both parameters were significantly reduced by 25 mg/kg, thus affirming the immunosuppressive properties of this substance in mice.
摘要
开展了多项研究以确定δ-9-四氢大麻酚（THC）对小鼠间接IgG噬斑形成细胞和玫瑰花结形成细胞产生的影响。用绵羊红细胞对BDF1小鼠进行免疫，随后多次注射10、25或40mg/kg的THC。结果表明，25mg/kg的THC可使这两个参数显著降低，从而证实了该物质在小鼠体内的免疫抑制特性。
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