Park Young Jun, Cho Yu Jin, Kwak Jinseul, Lim Youn-Hee, Park Minseon
Department of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea.
Korean J Fam Med. 2021 Jul;42(4):310-316. doi: 10.4082/kjfm.20.0180. Epub 2021 Jul 20.
In hemodialysis patients, brachial-ankle pulse wave velocity (baPWV) levels are affected by particulate matter with an aerodynamic diameter of 10 μm or less (PM10). We conducted this study to determine whether there is an association between short- and long-term PM10 exposure and baPWV in apparently healthy adults aged 40 years and older.
A total of 1,628 subjects who underwent health examinations between 2006 and 2009 were included in the study. On the basis of the day of medical screening, the 1-3-day and 365-day moving averages of PM10 concentrations were used to evaluate the association between short- and long-term exposure to PM10 and high baPWV (≥the third quartile of baPWV, 1,534 cm/s) using logistic regression models. Additional subgroup analyses were conducted according to age, sex, obesity (body mass index ≥25.0 kg/m2), and comorbidities such as metabolic syndrome.
No statistically significant associations were identified between short-term and long-term exposure to PM10 and baPWV in any of the subjects and subgroups. A 10-μg/m3 increase in the 2-day moving average of PM10 exposure was marginally associated with high baPWV in non-obese subjects (odds ratio, 1.059; P=0.058). This association in non-obese subjects was significantly different from that in obese subjects (P=0.038).
This study did not show statistically significant associations between short-term and long-term exposure to PM10 and baPWV in apparently healthy subjects. With short-term exposure to PM10, non-obese subjects showed a marginally unfavorable association with baPWV. Further studies are necessary to validate and elucidate the mechanism underlying the effect of PM10 on baPWV.
在血液透析患者中，肱踝脉搏波速度（baPWV）水平受空气动力学直径为10μm或更小的颗粒物（PM10）影响。我们开展本研究以确定40岁及以上看似健康的成年人短期和长期暴露于PM10与baPWV之间是否存在关联。
本研究纳入了2006年至2009年间接受健康检查的1628名受试者。根据医疗筛查日，使用PM10浓度的1 - 3天和365天移动平均值，通过逻辑回归模型评估短期和长期暴露于PM10与高baPWV（≥baPWV的第三个四分位数，1534 cm/s）之间的关联。根据年龄、性别、肥胖（体重指数≥25.0 kg/m²）以及代谢综合征等合并症进行了额外的亚组分析。
在任何受试者和亚组中，均未发现短期和长期暴露于PM10与baPWV之间存在统计学显著关联。在非肥胖受试者中，PM10暴露的2天移动平均值每增加10μg/m³与高baPWV存在微弱关联（比值比，1.059；P = 0.058）。非肥胖受试者中的这种关联与肥胖受试者中的关联显著不同（P = 0.038）。
本研究未显示在看似健康的受试者中短期和长期暴露于PM10与baPWV之间存在统计学显著关联。短期暴露于PM10时，非肥胖受试者与baPWV存在微弱的不利关联。需要进一步研究来验证和阐明PM10对baPWV影响的潜在机制。
