School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, P. R. China.
Biofouling. 2021 Jul;37(6):666-679. doi: 10.1080/08927014.2021.1955249. Epub 2021 Jul 28.
Paeonol, the active ingredient of root bark, is widely used in traditional Chinese medicine. Few studies have reported the antibacterial activity of paeonol against bacterial pathogens. In this study, the antibacterial and anti-biofilm performance of paeonol against and was investigated as well as its mechanisms of action. Paeonol effectively inhibited the growth of and with a minimum inhibitory concentration of 64 μg ml and it was shown to disrupt the integrity of bacterial cell membranes, and alter cell morphology. Moreover, paeonol exhibited a potent inhibitory effect against adhesion and biofilm formation by and . In particular, paeonol efficiently compromised cells within biofilms, and dispersed mature biofilms. Therefore, the present study suggests that paeonol is a promising alternative antibacterial and anti-biofilm agent for combating infections caused by planktonic and biofilm cells of and .
丹皮酚是根皮的活性成分，广泛应用于中药。鲜有研究报道丹皮酚对细菌病原体的抗菌活性。在这项研究中，研究了丹皮酚对和的抗菌和抗生物膜性能及其作用机制。丹皮酚能有效抑制和的生长，最低抑菌浓度为 64μg ml，能破坏细菌细胞膜的完整性，改变细胞形态。此外，丹皮酚对和的黏附和生物膜形成有很强的抑制作用。特别是，丹皮酚能有效地破坏生物膜内的细胞，并使成熟的生物膜解聚。因此，本研究表明，丹皮酚是一种很有前途的替代抗菌和抗生物膜剂，可用于对抗浮游和生物膜细胞引起的感染。
