Brown W R, Shivji G M, Furukawa R D, Ramsay C A
Department of Medicine, University of Toronto, Canada.
Photodermatol. 1987 Aug;4(4):196-200.
We have developed a new system, using ear swelling in mice, to study the action spectrum for the induction of photosensitivity to tetrachlorosalicylanilide (TCSA). Using narrow-band interference filters, we produced data for action spectra between 250 nm and 421 nm with doses of 0.5 J/cm2 and 0.2 J/cm2. We found that the higher dose generally produced greater reactions. The action spectrum was similar to the absorption spectrum for TCSA in the UVA region. The reduced responses in the UVB and UVC regions may be due to immunological suppression produced by these parts of the spectrum.
我们开发了一种新系统，利用小鼠耳部肿胀来研究对四氯水杨酰苯胺（TCSA）光敏化诱导的作用光谱。使用窄带干涉滤光片，我们得出了剂量为0.5 J/cm²和0.2 J/cm²时250纳米至421纳米之间的作用光谱数据。我们发现较高剂量通常会产生更大的反应。该作用光谱与TCSA在UVA区域的吸收光谱相似。UVB和UVC区域反应减弱可能是由于这些光谱部分产生的免疫抑制作用。
