F-FDG PET/CT代谢及容积参数在非小细胞肺癌中的影响因素及预后价值
Influencing Factors and Prognostic Value of F-FDG PET/CT Metabolic and Volumetric Parameters in Non-Small Cell Lung Cancer.
作者信息
Zhang Lixia, Ren Zhe, Xu Caiyun, Li Qiushuang, Chen Jinyan
机构信息
Department of Nuclear Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006, People's Republic of China.
Department of Chest Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006, People's Republic of China.
出版信息
Int J Gen Med. 2021 Jul 21;14:3699-3706. doi: 10.2147/IJGM.S320744. eCollection 2021.
OBJECTIVE
This study aims to explore factors influencing metabolic and volumetric parameters of [F]fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) imaging in non-small cell lung cancer (NSCLC) and the predictive value for prognosis of NSCLC.
METHODS
Retrospective analysis was performed on 133 NSCLC patients who received F-FDG PET/CT imaging. After F-FDG injection at 3.7 MBq/kg, 1 h early imaging and 2 h delayed imaging were performed. The metabolic and volumetric parameters such as SUVmax, SUVpeak, SULmax, SULpeak, MTV and TLG were measured. The tumor markers including CFYRA21-1, NSE, SCC-ag and the immunohistochemical biomarkers including Ki-67, P53 and CK-7 were examined. All patients were followed up for 24 months, and the 1-year and 2-year overall survival rate (OS) were recorded.
RESULTS
There were significant differences in metabolic and volumetric parameters (SUVmax, SUVpeak, SULmax, SULpeak and TLG) between adenocarcinoma and squamous cell carcinoma of NSCLC. SUVmax, SUVpeak, SULmax, SULpeak, MTV and TLG were correlated with tumor marker NSE and TNM stage. MTV and TLG were related to CYFRA21-1, and only MTV was associated with SCC-ag. SUVpeak and SULmax were related to P53. In addition, early SULpeak and delayed MTV were significant prognostic factors of 1-year OS, while early SUVpeak, delayed TLG and delayed MTV were predictive factors of 2-year OS in NSCLC.
CONCLUSION
The metabolic and volumetric parameters of F-FDG PET/CT were related to a variety of factors such as NSE, CFYRA21-1, SCC-ag, P53 and TNM stage, and have a predictive value in prognosis of NSCLC.
目的
本研究旨在探讨影响非小细胞肺癌（NSCLC）[F]氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）成像代谢和容积参数的因素以及对NSCLC预后的预测价值。
方法
对133例接受F-FDG PET/CT成像的NSCLC患者进行回顾性分析。按3.7 MBq/kg注射F-FDG后，进行1小时早期成像和2小时延迟成像。测量SUVmax、SUVpeak、SULmax、SULpeak、MTV和TLG等代谢和容积参数。检测肿瘤标志物包括细胞角蛋白19片段（CYFRA21-1）、神经元特异性烯醇化酶（NSE）、鳞状上皮细胞癌抗原（SCC-ag），以及免疫组化生物标志物包括Ki-67、P53和细胞角蛋白7（CK-7）。对所有患者随访24个月，记录1年和2年总生存率（OS）。
结果
NSCLC腺癌和鳞癌之间的代谢和容积参数（SUVmax、SUVpeak、SULmax、SULpeak和TLG）存在显著差异。SUVmax、SUVpeak、SULmax、SULpeak、MTV和TLG与肿瘤标志物NSE和TNM分期相关。MTV和TLG与CYFRA21-1有关，仅MTV与SCC-ag相关。SUVpeak和SULmax与P53有关。此外，早期SULpeak和延迟MTV是1年OS的显著预后因素，而早期SUVpeak、延迟TLG和延迟MTV是NSCLC患者2年OS的预测因素。
结论
F-FDG PET/CT的代谢和容积参数与NSE、CYFRA21-1、SCC-ag、P53和TNM分期等多种因素相关，对NSCLC预后具有预测价值。
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