Splinter T A, Noorloos B V, Van Heerde P
Scand J Haematol. 1978 Jan;20(1):29-36. doi: 10.1111/j.1600-0609.1978.tb01551.x.
A case report is presented of a 77-year-old woman suffering from a composite lymphoma, known as Richter's Syndrome, consisting of chronic lymphocytic leukaemia (CLL) and diffuse histiocytic lymphoma. Light-microscopic investigation revealed the presence of CLL cells in the blood and bone marrow and a combination of CLL cells and large immunoblastic cells in the lymph node. Immunological investigation showed that both malignant cell types were B cells. The CLL cells carried a monoclonal surface immunoglobulin (S-Ig) micron lambda, and the immunoblastic cells had a monoclonal S-Ig micron K. These findings indicated that both clonal lymphoproliferative diseases were probably derived from different tumour stem cells.
本文报告了一例77岁女性患有复合淋巴瘤，即里氏综合征，其由慢性淋巴细胞白血病（CLL）和弥漫性组织细胞淋巴瘤组成。光镜检查显示血液和骨髓中存在CLL细胞，淋巴结中存在CLL细胞和大免疫母细胞的组合。免疫学检查表明两种恶性细胞类型均为B细胞。CLL细胞携带单克隆表面免疫球蛋白（S-Ig）μλ，免疫母细胞具有单克隆S-Igμκ。这些发现表明这两种克隆性淋巴细胞增殖性疾病可能源自不同的肿瘤干细胞。
