Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.
Department of Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Environ Sci Pollut Res Int. 2021 Dec;28(46):65731-65742. doi: 10.1007/s11356-021-15302-6. Epub 2021 Jul 28.
Anemia is a public health problem that affects many people worldwide. Beetroot (Beta vulgaris) is a plant supposed to have many healthy features. The present study was done to evaluate the anti-anemic effect of beetroot supplement on anemia induced by phenylhydrazine in albino rats. Fifty rats were randomly divided into five equal groups. The control group was kept normal rats. In the second group, anemia was induced in rats by intraperitoneal injection of phenylhydrazine at 60 mg/kg in 3 divided doses daily, for 3 consecutive days. The last three groups received phenylhydrazine as the anemic group. Then, the third group received beetroot extract in dose 200 mg/kg for 24 days. The fourth group received beetroot powder in dose 1000 mg/kg for 24 days. The last group received iron (III) hydroxide polymaltose complex in dose 5mg/kg for 24 days. Our results showed that hemolytic anemia induced by phenylhydrazine in rats caused alteration in the blood picture, iron indices, serum biochemical parameters, antioxidant biomarkers, and histopathological picture. However, the supplementation with beetroot ameliorated these alterations, especially beetroot powder which showed powerful health effects compared to beetroot extract and iron preparation.
贫血是一个影响全球许多人的公共健康问题。甜菜根（Beta vulgaris）是一种被认为具有许多健康特性的植物。本研究旨在评估甜菜根补充剂对苯肼诱导的白化大鼠贫血的抗贫血作用。50 只大鼠被随机分为五组，每组 10 只。对照组为正常大鼠。第二组大鼠每天腹腔注射苯肼 60mg/kg，分 3 次，连续 3 天，诱导贫血。后三组大鼠接受苯肼作为贫血组。第三组大鼠给予甜菜根提取物 200mg/kg，连续 24 天。第四组大鼠给予甜菜根粉 1000mg/kg，连续 24 天。最后一组大鼠给予三价铁（III）羟基麦芽多糖复合物 5mg/kg，连续 24 天。我们的结果表明，苯肼诱导的大鼠溶血性贫血导致血液学参数、铁指标、血清生化参数、抗氧化生物标志物和组织病理学图片改变。然而，甜菜根的补充改善了这些改变，尤其是甜菜根粉，与甜菜根提取物和铁制剂相比，表现出更强的健康作用。
