Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Faculty of Pharmacy, Salim Habib University, Karachi, Pakistan.
Pak J Pharm Sci. 2021 Sep;34(5(Supplementary)):1917-1922.
Beta vulgaris L. is a vegetable most commonly consumed in salads and has been shown to possess multiple benefits. This research was carried out to observe the effects of Beta vulgaris powder at different doses orally in albino rabbits on liver biochemical parameters and coagulation. The study was carried out on albino rabbits which were divided into three groups designated as Group I (administered distilled water) Group II and III (administered beetroot powder at 500mg/kg and 1000mg/kg dose respectively) orally for 2 month duration. The sample was withdrawn at day 0, 30th and 60th day through cardiac puncture. The results showed that both doses of Beta vulgaris were considered safe for use as all the liver parameters were significantly decreased compared to control. Among both doses 500mg/kg dose was considered safer as it reduced the parameters significantly compared to 1000mg/kg dose. Blood coagulation factors at both the doses showed significant increase which was in reference range. Beta vulgaris is a highly beneficial dietary product with ample amount of flavonoids and anti-oxidant agents which might help in improving the liver function and also play a role in coagulation by increasing both fibrinogen levels and prothrombin time.
蕹菜是一种最常食用的蔬菜，具有多种益处。本研究旨在观察不同剂量蕹菜粉对大白兔肝脏生化参数和凝血功能的影响。将大白兔分为三组，分别为 I 组（给予蒸馏水）、II 组和 III 组（分别给予 500mg/kg 和 1000mg/kg 的蕹菜粉），口服给药 2 个月。通过心脏穿刺在第 0、30 和 60 天抽取样本。结果表明，两种剂量的蕹菜均被认为是安全的，因为与对照组相比，所有肝脏参数均显著降低。在这两种剂量中，500mg/kg 的剂量被认为更安全，因为它与 1000mg/kg 的剂量相比，显著降低了这些参数。两种剂量的凝血因子均显著增加，处于参考范围。蕹菜是一种非常有益的膳食产品，含有丰富的类黄酮和抗氧化剂，可能有助于改善肝功能，同时通过增加纤维蛋白原水平和凝血酶原时间在凝血中发挥作用。
