Department of Biochemistry, Faculty of Biological Sciences, Abia State University, Uturu, Abia, Nigeria.
Department of Public Health, Faculty of Health Sciences, Abia State University, Uturu, Abia, Nigeria.
Drug Metab Pers Ther. 2021 Apr 9;36(4):311-320. doi: 10.1515/dmpt-2020-0185.
L. is used in traditional medicine for the treatment of bacterial infections and anaemia. This study was designed to evaluate the effect of leaf extract on phenylhydrazine (PHZ)-induced anaemia and toxicity in rats.
The experimental rats were divided into five groups (A-E) (n=6/sex/group). Each rat in groups B-E was intraperitoneally administered 50 mg/kg of PHZ for two consecutive days. Group A (normal control) did not receive any PHZ, group B (negative control), group C received orally 5 mg/kg ferrous sulphate whereas groups D and E received 200 and 400 mg/kg leaf extract respectively, for 14 days.
Red blood cell count, packed cell volume, haemoglobin concentration and high-density lipoprotein increased significantly (p<0.05) whereas low-density lipoprotein and very-low-density lipoprotein decreased in extract-treated groups when compared to the negative control. (400 mg/kg extract) and standard drug (5 mg/kg ferrous sulphate) significantly (p<0.05) reduced the levels of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase.
The results of this study indicate that leaf extract has a restorative effect on the phenylhydrazine-induced metabolic distortions in the blood, liver, and kidney, and therefore could be used therapeutically as an anti-anaemic tonic.
L. 在传统医学中用于治疗细菌感染和贫血。本研究旨在评估叶提取物对苯肼（PHZ）诱导的贫血和大鼠毒性的影响。
实验大鼠分为五组（A-E）（每组 n=6/性别）。B-E 组大鼠连续两天腹腔注射 50mg/kg PHZ。A 组（正常对照组）未给予任何 PHZ，B 组（阴性对照组）、C 组给予 5mg/kg 硫酸亚铁口服，D 组和 E 组分别给予 200 和 400mg/kg 叶提取物，连续 14 天。
与阴性对照组相比，红细胞计数、红细胞压积、血红蛋白浓度和高密度脂蛋白显著增加（p<0.05），而低密度脂蛋白和极低密度脂蛋白则降低。（400mg/kg 提取物）和标准药物（5mg/kg 硫酸亚铁）显著降低了天冬氨酸转氨酶、丙氨酸转氨酶和碱性磷酸酶的水平。
本研究结果表明，叶提取物对苯肼诱导的血液、肝脏和肾脏代谢紊乱具有修复作用，因此可作为一种治疗贫血的滋补品。
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