Ogura Ayano, Yamaguchi Seiji, Le Phuc Thi Minh, Yamamoto Kayoko, Omori Michi, Inoue Kazuya, Kato-Kogoe Nahoko, Nakajima Yoichiro, Nakano Hiroyuki, Ueno Takaaki, Yamada Tomohiro, Mori Yoshihide
Department of Dentistry and Oral Surgery, Division of Medicine for Function and Morphology of Sensory Organs, Faculty of Medicine, Osaka Medical College, Takatsuki, Japan.
Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
J Biomed Mater Res B Appl Biomater. 2022 Feb;110(2):392-402. doi: 10.1002/jbm.b.34915. Epub 2021 Jul 29.
Grit-blasted/acid-etched titanium dental implants have a moderately roughened surface that is suitable for cell adhesion and exhibits faster osseointegration. However, the roughened surface does not always maintain stable fixation over a long period. In this study, a simple heat treatment at 600°C was performed on a commercially available dental Ti implant with grit-blasting/acid-etching, and its effect on mineralization capacity was assessed by examining apatite formation in a simulated body fluid (SBF). The as-purchased implant displayed a moderately roughened surface at the micrometer scale. Its surface was composed of titanium hydride accompanied by a small amount of alumina particles derived from the grit-blasting. Heat treatment transformed the titanium hydride into rutile without evidently changing the surface morphology. The immersion in SBF revealed that apatite formed on the heated implant at 7 days. Furthermore, apatite formed on the Ti rod surface within 1 day when the metal was subjected to acid and heat treatment without blasting. These indicate that apatite formation was conferred on the commercially available dental implant by simple heat treatment, although its induction period was slightly affected by alumina particles remaining on the implant surface. The heat-treated implant should achieve stronger and more stable bone bonding due to its apatite formation.
喷砂/酸蚀钛牙种植体具有适度粗糙的表面，适合细胞粘附且骨结合更快。然而，这种粗糙表面并不总是能长期保持稳定固定。在本研究中，对市售的经喷砂/酸蚀处理的牙科钛种植体进行了600°C的简单热处理，并通过检测模拟体液（SBF）中的磷灰石形成来评估其对矿化能力的影响。购买的种植体在微米尺度上呈现出适度粗糙的表面。其表面由氢化钛组成，并伴有少量源自喷砂的氧化铝颗粒。热处理将氢化钛转变为金红石，而表面形态没有明显变化。在SBF中浸泡显示，加热后的种植体在7天时形成了磷灰石。此外，当金属在未喷砂的情况下进行酸处理和热处理时，钛棒表面在1天内就形成了磷灰石。这些表明，简单的热处理赋予了市售牙科种植体形成磷灰石的能力，尽管其诱导期受到种植体表面残留氧化铝颗粒的轻微影响。经过热处理的种植体由于其磷灰石形成，应该能实现更强、更稳定的骨结合。
