Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
Department of Natural Sciences, Mid Sweden University, 85170, Sundsvall, Sweden.
Chemistry. 2021 Oct 1;27(55):13725-13729. doi: 10.1002/chem.202102483. Epub 2021 Sep 6.
Herein, an iron(II)-catalyzed biomimetic oxidation of N-heterocycles under aerobic conditions is described. The dehydrogenation process, involving several electron-transfer steps, is inspired by oxidations occurring in the respiratory chain. An environmentally friendly and inexpensive iron catalyst together with a hydroquinone/cobalt Schiff base hybrid catalyst as electron-transfer mediator were used for the substrate-selective dehydrogenation reaction of various N-heterocycles. The method shows a broad substrate scope and delivers important heterocycles in good-to-excellent yields.
本文描述了在有氧条件下铁(II)催化的仿生 N-杂环氧化反应。该脱氢过程涉及多个电子转移步骤，灵感来自于呼吸链中发生的氧化反应。使用环境友好且廉价的铁催化剂和对苯二酚/钴席夫碱混合催化剂作为电子转移介质，实现了各种 N-杂环的底物选择性脱氢反应。该方法具有广泛的底物范围，能以良好至优异的收率得到重要的杂环化合物。
