Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Instituto de Física e Química, Universidade Federal de Itajubá, Itajubá, Minas Gerais, Brazil.
J Ethnopharmacol. 2021 Nov 15;280:114460. doi: 10.1016/j.jep.2021.114460. Epub 2021 Jul 26.
Ethanolic extract of aerial parts from Lychnophora pinaster Mart. are used in traditional Brazilian medicine for treating pain, rheumatism and inflammation.
Drugs for the treatment of gout present severe adverse effects, justifying the need to search for new therapeutic options. The aim of the present study was to evaluate the effects of the ethanolic extract of L. pinaster and its main constituents in arthritis induced in mice by the injection of monosodium urate (MSU) crystals.
Antinociceptive effect was investigated using an electronic pressure-meter nociception paw test in C57BL/6 mice. Anti-gouty arthritis was investigated in mice induced with gout by the injection of MSU crystals into their femur-tibial tissue. Ethanolic extract of the aerial parts of Lychnophora pinaster and its main chemical constituents were evaluated as treatment.
The ethanolic extract and their main chemical constituents inhibited neutrophil migration, reduced IL-1β and TNF-α concentrations in the inflamed tissue and showed antinociceptive activity.
Gouty arthritis effects of the ethanolic extract can be attached to a synergistic effect of terpenes, flavonoids and phenolic acids present in the extract. Results obtained support the use of this extract and its main chemical constituents in the treatment of gout, inflammation, and pain.
从石栗 Lychnophora pinaster Mart. 的地上部分提取的乙醇提取物，在传统的巴西医学中用于治疗疼痛、风湿和炎症。
治疗痛风的药物会产生严重的不良反应，这证明有必要寻找新的治疗选择。本研究的目的是评估乙醇提取物及其主要成分对尿酸单钠 (MSU) 晶体注射诱导的关节炎小鼠的影响。
使用 C57BL/6 小鼠的电子压力计痛觉足部测试来研究镇痛作用。通过向股骨-胫骨组织注射 MSU 晶体来诱导痛风，研究抗痛风关节炎。评估了 Lychnophora pinaster 的地上部分的乙醇提取物及其主要化学成分为治疗药物。
乙醇提取物及其主要化学成分抑制中性粒细胞迁移，减少炎症组织中 IL-1β 和 TNF-α 的浓度，并具有镇痛活性。
乙醇提取物对痛风性关节炎的作用可能归因于提取物中存在的萜类、类黄酮和酚酸的协同作用。所得结果支持使用该提取物及其主要化学成分治疗痛风、炎症和疼痛。
