Mendes Roncada Eduardo V, Brambilla Victoria Romanini, Freitas Filitto Beatriz, Genta Mariana Pirajá, Morgado de Abreu Marilda Ap M
Departament of Dermatology, UNOESTE - Universidade do Oeste Paulista, Hospital Regional de Presidente Prudente, São Paulo, Brazil.
Case Rep Dermatol. 2021 Jul 9;13(2):336-339. doi: 10.1159/000513467. eCollection 2021 May-Aug.
In the therapeutic arsenal to treat moderate to severe psoriasis, the new agents are secukinumab and ustekinumab, which are fully human monoclonal antibodies, directed against IL-17A and IL-12/23, respectively, which have been shown to be effective and safe in several studies. Their side effects are rare, and the most frequently reported side effects were infection, especially nasopharyngitis, headache, pruritus, high blood pressure, and low back pain. Unlike the side effects, the paradoxical reaction can be defined by the appearance or exacerbation of a pathological condition that usually responds to a certain class of drug. The appearance of this reaction in patients using anti-interleukins is poorly described; however, as they are new drugs, they may be more common than the literature reports. We describe a case of a paradoxical reaction, with the appearance of atopic dermatitis, after using secukinumab to treat psoriasis.
在治疗中度至重度银屑病的治疗手段中，新的药物是司库奇尤单抗和优特克单抗，它们是完全人源化单克隆抗体，分别针对白细胞介素-17A和白细胞介素-12/23，多项研究表明它们有效且安全。它们的副作用罕见，最常报告的副作用是感染，尤其是鼻咽炎、头痛、瘙痒、高血压和腰痛。与副作用不同，矛盾反应可定义为通常对某类药物有反应的病理状况的出现或加重。使用抗白细胞介素药物的患者中这种反应的出现情况描述较少；然而，由于它们是新药，可能比文献报道的更为常见。我们描述了一例在使用司库奇尤单抗治疗银屑病后出现特应性皮炎这一矛盾反应的病例。
