Luo Meijunzi, Zeng Bijun, Wang Haizhen, Yang Zhibo, Peng Youhua, Zhang Yujin, Wang Chang
Department of Dermatology, The Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan 410005, China.
Evid Based Complement Alternat Med. 2021 Jul 16;2021:5522164. doi: 10.1155/2021/5522164. eCollection 2021.
Psoriasis is a chronic, recurrent, immunoinflammatory disease. For a long period, Traditional Chinese Medicine (TCM) is considered a reliable alternative therapy for patients with psoriasis. Fructus Kochiae (or ) and its principle saponin, Momordin Ic, have been reported to protect against inflammation. Herein, we demonstrated that Momordin Ic could inhibit HaCaT cell proliferation and enhance cell apoptosis. In the meantime, Momordin Ic alters Wnt/-catenin pathway activation by affecting -catenin nuclear distribution. The Wnt/-catenin signaling activator LiCl partially reversed the effects of Momordin Ic on HaCaT phenotypes and the Wnt/-catenin pathway factors. Altogether, we demonstrate the inhibitory effects of Momordin Ic, one of the major saponin constituents of Fructus Kochiae, on HaCaT cell proliferation and Momordin Ic-induced alteration within the Wnt/-catenin pathway. Momordin Ic might act on HaCaT cells by modulating the Wnt/-catenin pathway.
银屑病是一种慢性、复发性免疫炎症性疾病。长期以来，中医被认为是银屑病患者可靠的替代疗法。地肤子及其主要皂苷成分木鳖子苷Ic已被报道具有抗炎作用。在此，我们证明木鳖子苷Ic可抑制HaCaT细胞增殖并增强细胞凋亡。同时，木鳖子苷Ic通过影响β-连环蛋白核分布改变Wnt/β-连环蛋白信号通路激活。Wnt/β-连环蛋白信号激活剂LiCl部分逆转了木鳖子苷Ic对HaCaT细胞表型和Wnt/β-连环蛋白信号通路因子的影响。总之，我们证明了地肤子主要皂苷成分之一木鳖子苷Ic对HaCaT细胞增殖的抑制作用以及木鳖子苷Ic诱导的Wnt/β-连环蛋白信号通路改变。木鳖子苷Ic可能通过调节Wnt/β-连环蛋白信号通路作用于HaCaT细胞。
