School of Pharmacy,Tianjin Medical University, Tianjin, China.
TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, China.
PLoS One. 2023 Aug 29;18(8):e0290637. doi: 10.1371/journal.pone.0290637. eCollection 2023.
Glycyrrhetinic acid, a drug with anti-inflammatory effects, enhanced the activity of antipsoriatic efficacy. In this research, an ointment with glycyrrhetinic acid was prepaired as the major component and several other herbal monomers (astilbin, osthole, and momordin Ic) have antipsoriatic activity as minor components. Then an Imiquimod-induced psoriasis-like mouse model was established and the damaged skin condition of the administered group, the changes in the spleen index and the secretion of inflammatory factors in mouse skin were observed. Calcipotriol ointment was used as a positive control to compare the efficacy. Glycyrrhizic acid compound ointment significantly improved imiquimod-induced psoriasis in mice and reduced the secretion of TNF-α, IL-12, IL-17, and IL-23 in mouse skin, and showed a stronger therapeutic effect than calcipotriol ointment. Calcipotriol ointment did not significantly alleviate imiquimod-induced splenomegaly and did not significantly reduce the expression of IL-17 and IL-23 in mouse skin. Glycyrrhetinic acid compound ointment was more effective than calcipotriol and was dose-dependent in the treatment of imiquimod-induced psoriatic dermatitis in mice. Meanwhile,calcipotriol was not suitable for the treatment of Imiquimod -induced psoriasis-like mice.
甘草酸作为一种具有抗炎作用的药物，增强了抗银屑病的疗效。在这项研究中，以甘草酸为主要成分制备了一种软膏，同时还有几种具有抗银屑病活性的草药单体（虎杖苷、蛇床子素和棉子糖 Ic）作为次要成分。然后建立了咪喹莫特诱导的银屑病样小鼠模型，观察给药组的受损皮肤状况、脾脏指数变化以及小鼠皮肤中炎症因子的分泌情况。卡泊三醇软膏作为阳性对照进行比较疗效。甘草酸复方软膏显著改善了咪喹莫特诱导的小鼠银屑病，减少了 TNF-α、IL-12、IL-17 和 IL-23 在小鼠皮肤中的分泌，并且显示出比卡泊三醇软膏更强的治疗效果。卡泊三醇软膏并没有显著减轻咪喹莫特诱导的脾肿大，也没有显著降低小鼠皮肤中 IL-17 和 IL-23 的表达。甘草酸复方软膏在治疗咪喹莫特诱导的银屑病性皮肤病方面比卡泊三醇更有效，且具有剂量依赖性。同时，卡泊三醇不适合治疗咪喹莫特诱导的银屑病样小鼠。
