Ottaiano Alessandro, Santorsola Mariachiara, Perri Francesco, Pace Ugo, Marra Bruno, Correra Marco, Sabbatino Francesco, Cascella Marco, Petrillo Nadia, Ianniello Monica, Casillo Marika, Misso Gabriella, Delrio Paolo, Caraglia Michele, Nasti Guglielmo
Istituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", Via M. Semmola, 80131 Naples, Italy.
Oncology Unit, San Giovanni di Dio e Ruggi D'Aragona University Hospital, Universisty of Salerno, 84131 Salerno, Italy.
Biology (Basel). 2022 Feb 8;11(2):267. doi: 10.3390/biology11020267.
The most frequent form of colorectal cancer is represented by adenocarcinoma being about 98% of tumor histological types. However, other rare histotypes can be found in colon and rectum (adenosquamous, goblet cell adenocarcinoma, lymphoma, medullary carcinoma, melanoma, mesenchymal, neuroendocrine, plasmacytoma, signet ring, squamous tumors). Altogether, these forms account for less than 2% of colorectal tumors. There are no specific diagnostic or therapeutic recommended approaches and most of the information available from literature derives from small and retrospective clinical series. In the present study, we provide a paramount and updated view on clinical and biologic characteristics of rare colorectal tumors.
结直肠癌最常见的形式是腺癌，约占肿瘤组织学类型的98%。然而，在结肠和直肠中也可发现其他罕见的组织学类型（腺鳞癌、杯状细胞腺癌、淋巴瘤、髓样癌、黑色素瘤、间叶性肿瘤、神经内分泌肿瘤、浆细胞瘤、印戒细胞癌、鳞状肿瘤）。这些类型总共占结直肠肿瘤的比例不到2%。目前尚无特异性的诊断或治疗推荐方法，文献中的大多数信息来自小型回顾性临床系列研究。在本研究中，我们提供了关于罕见结直肠肿瘤临床和生物学特征的重要且最新的观点。
