Lakshmanan Suvasini, Kinninger April, Golub Ilana, Dahal Suraj, Birudaraju Divya, Ahmad Khadije, Ghanem Ahmad K, Rezvanizadeh Vahid, Roy Sion K, Budoff Matthew J
Lundquist Institute of Biomedical Innovation and Research at Harbor UCLA Medical Center, Torrance, CA, USA.
Am J Prev Cardiol. 2020 Oct 21;4:100098. doi: 10.1016/j.ajpc.2020.100098. eCollection 2020 Dec.
Blue zones are longevity hotspots around the world characterized by highest concentrations of healthy centenarians. Certified blue zone communities are designed by implementation of environmental and policy changes that promote healthy behaviors.
To examine the trends of prevalence of zero CAC, a marker of ideal cardiovascular and overall health status and burden of cardiovascular risk factors in Beach Cities/certified blue zones of Southern California and rest of California.
This is a population-based cohort study of persons aged 50 years or older in California, who underwent CAC screening between 2000 and 2019. A total of 3864 participants from Beach Cities of Southern California were identified by Zip Codes and compared with 35,537 participants from rest of California. We compared trends of prevalence of zero CAC and cardiovascular risk factors between the two groups, in 5-year intervals.
Among 39,401 participants (mean age, 58.1 years; 36% women), 13,374 (34%) had zero CAC. The prevalence of CAC = 0 was significantly higher in Beach Cities compared to the rest of California (p < 0.001). Across the study period, the prevalence of cardiac risk factors including obesity, smoking, diabetes and hypertension remain significantly lower in Beach Cities. (p < 0.001).
This study, shows for the first time, that higher prevalence of zero CAC in Beach Cities of California, adds validity to excellent prognosis and longevity in these areas. The impact of policy implementation and environmental changes on lifestyle patterns, cardiovascular health and healthy ageing needs to be evaluated.
蓝色区域是世界各地的长寿热点地区，其特点是健康的百岁老人集中度最高。经过认证的蓝色区域社区是通过实施促进健康行为的环境和政策变化来设计的。
研究零冠状动脉钙化（CAC）的患病率趋势，零CAC是理想心血管和整体健康状况的标志物，也是南加州海滩城市/认证蓝色区域及加州其他地区心血管危险因素的负担。
这是一项基于人群的队列研究，研究对象为加利福尼亚州50岁及以上的人群，他们在2000年至2019年间接受了CAC筛查。通过邮政编码确定了来自南加州海滩城市的3864名参与者，并与来自加州其他地区的35537名参与者进行了比较。我们以5年为间隔比较了两组之间零CAC患病率和心血管危险因素的趋势。
在39401名参与者（平均年龄58.1岁；36%为女性）中，13374名（34%）的CAC为零。与加州其他地区相比，海滩城市中CAC = 0的患病率显著更高（p < 0.001）。在整个研究期间，海滩城市中心脏病危险因素（包括肥胖、吸烟、糖尿病和高血压）的患病率仍然显著较低（p < 0.001）。
本研究首次表明，加利福尼亚州海滩城市中零CAC的患病率较高，为这些地区良好的预后和长寿增添了可信度。需要评估政策实施和环境变化对生活方式模式、心血管健康和健康老龄化的影响。
