Department of Economics, University of South Florida, Tampa, Florida, USA.
Health Services Research Center, Akershus University Hospital, Lørenskog, Norway.
Patient. 2022 Mar;15(2):187-196. doi: 10.1007/s40271-021-00541-z. Epub 2021 Jul 30.
Stated preference research currently lacks a form of evidence that is well suited for small samples. A preference path is a sequence of two or more choices showing the evolution of an object following an adaptive process.
The aims were to introduce preference paths and their kaizen tasks and to demonstrate how to analyze their evidence using a small sample.
Twenty respondents were assigned the same 16 profiles generated from an orthogonal array based on the five attributes of the EQ-5D-5L descriptive system. Each kaizen task began with an opt-out paired comparison (i.e., choosing between the initial 10-year profile and the opt-out "dying immediately"), followed by choosing three changes, and ended with a second paired comparison (final profile versus opt-out) if the respondent chose opt-out initially. By maximum likelihood with respondent clusters, we estimated the 20 main effects using conditional logit and Zermelo-Bradley-Terry (ZBT) specifications.
Apart from demonstrating heterogeneity and profile effects, all main effect estimates were non-negative, and most were significant (15 for logit and all 20 for ZBT; p value < 0.05). Under the logit and ZBT specifications, the value of the worst EQ-5D-5L profile (55555) is - 0.920 quality-adjusted life years (QALYs) or - 1.478 QALYs, respectively. Furthermore, the findings illustrate a log-linear relationship between the logit and ZBT main effects.
This paper demonstrates the feasibility of a stated-preference study that estimates 20 main effects using path evidence from 20 respondents (16 kaizen tasks, 15-min interviews). This approach shows promise for future application in stated-preference research, particularly in small samples.
目前,陈述偏好研究缺乏一种非常适合小样本的证据形式。偏好路径是指在自适应过程中展示对象演变的两个或多个选择的序列。
旨在引入偏好路径及其改善任务,并展示如何使用小样本分析其证据。
20 名受访者被分配了相同的 16 个配置文件,这些配置文件是基于 EQ-5D-5L 描述系统的五个属性从正交数组中生成的。每个改善任务都从一个退出配对比较开始(即,在初始 10 年的配置文件和退出“立即死亡”之间进行选择),然后选择三个变化,最后在受访者最初选择退出时进行第二次配对比较(最终配置文件与退出)。通过带有受访者聚类的最大似然法,我们使用条件逻辑和 Zermelo-Bradley-Terry(ZBT)规范估计了 20 个主要效应。
除了展示异质性和配置文件效应外,所有主要效应估计值均为非负,且大多数均显著(逻辑回归为 15 个,ZBT 为所有 20 个;p 值<0.05)。在逻辑回归和 ZBT 规范下,最差 EQ-5D-5L 配置文件(55555)的价值为-0.920 质量调整生命年(QALY)或-1.478 QALY。此外,研究结果表明逻辑回归和 ZBT 主要效应之间存在对数线性关系。
本文展示了一种使用来自 20 名受访者(16 个改善任务,15 分钟访谈)的路径证据估计 20 个主要效应的陈述偏好研究的可行性。这种方法有望在未来的陈述偏好研究中得到应用,特别是在小样本中。