Department of Economics, University of South Florida, Tampa, FL.
Department of Health Management and Health Economics, University of Oslo, Oslo.
Med Care. 2018 Jun;56(6):529-536. doi: 10.1097/MLR.0000000000000912.
The 5-level version of the EQ-5D (EQ-5D-5L) was introduced as an improvement on the original 3-level version (EQ-5D-3L). To date, 6 country-specific value sets have been published for EQ-5D-5L and 9 US value sets have been published for other instruments. Our aims were to (1) produce EQ-5D-5L values on a quality-adjusted life year (QALY) scale from the perspective of US adults and (2) compare them with US EQ-5D-3L values and the other country-specific EQ-5D-5L values.
In 2016, 8222 US respondents from all 50 states and Washington, DC completed an online survey including a discrete choice experiment with 20 paired comparisons. Each comparison asked respondents, "Which do you prefer?" regarding a pair of alternatives described using EQ-5D-5L and lifespan attributes. On the basis of more than 50 choices on each of the 3160 pairs, we estimated EQ-5D-5L values on a QALY scale and compared them with the US EQ-5D-3L values and the other country-specific EQ-5D-5L values.
Ranging from -0.287 (55555) to 0.992 (11121) on a QALY scale, the estimated EQ-5D-5L values were similar to the US EQ-5D-3L values. Compared with the US EQ-5D-3L values, the values exhibited greater sensitivity and specificity and higher correlation with the EQ-5D-5L values of other countries, particularly England.
Like previous US valuation studies, this study produced nationally representative EQ-5D-5L values on a QALY scale. The results further demonstrate the advantages of the EQ-5D-5L over its 3-level predecessor as a preference-based summary measure of health-related quality of life from the perspective of US adults.
EQ-5D 的 5 级版本（EQ-5D-5L）作为原始 3 级版本（EQ-5D-3L）的改进版本推出。迄今为止，已为 EQ-5D-5L 发布了 6 个国家特定价值集，并且为其他工具发布了 9 个美国价值集。我们的目的是：（1）从美国成年人的角度生成 EQ-5D-5L 值在质量调整生命年（QALY）的尺度上；（2）并将其与美国 EQ-5D-3L 值和其他国家特定的 EQ-5D-5L 值进行比较。
在 2016 年，来自美国所有 50 个州和华盛顿特区的 8222 名受访者完成了一项在线调查，其中包括一项包含 20 对配对比较的离散选择实验。每对比较都要求受访者在使用 EQ-5D-5L 和寿命属性描述的一对替代方案中回答“您更喜欢哪一个？”。在对每个 3160 对中的每对进行超过 50 次选择的基础上，我们估计了 QALY 尺度上的 EQ-5D-5L 值，并将其与美国 EQ-5D-3L 值和其他国家特定的 EQ-5D-5L 值进行了比较。
在 QALY 尺度上，估计的 EQ-5D-5L 值从-0.287（55555）到 0.992（11121）不等，与美国 EQ-5D-3L 值相似。与美国 EQ-5D-3L 值相比，这些值具有更高的灵敏度和特异性，并且与其他国家的 EQ-5D-5L 值相关性更高，尤其是英国。
与之前的美国估值研究一样，本研究在 QALY 尺度上生成了具有全国代表性的 EQ-5D-5L 值。结果进一步证明，EQ-5D-5L 作为一种基于偏好的健康相关生活质量综合衡量标准，相对于其 3 级前身，从美国成年人的角度来看具有优势。
