Department of Economics, University of South Florida, Tampa, Florida, USA.
Department of Economics, University of South Florida, Tampa, Florida, USA
BMJ Open. 2023 Oct 24;13(10):e077256. doi: 10.1136/bmjopen-2023-077256.
A decade ago, the first national valuation study of the EQ-5D-Y-3L (Y-3L) involved a discrete choice experiment (DCE) that asked 4155 US adult respondents to complete 40 paired comparisons, choosing between two dying children. Instead of choosing between dying children, the respondents in this novel protocol are asked whether 'being in a coma' is better or worse than experiencing 'health problems' (ie, experience scale) and how they would relieve health problems (ie, kaizen tasks). Our aims are to compare the preference evidence of the paired comparison and kaizen tasks and to conduct a DCE for the valuation of Y-3L profiles on an experience scale.
Under this protocol, we will conduct an online survey that collects preference evidence from 600 US adult respondents on the health of a 10-year-old child for a week. Across all scenarios, each child will be described as either being 'in a coma' or having 'health problems', namely five three-level attributes (Y-3L). In this DCE, each respondent will be randomly assigned to one of four D-efficient blocks, including five coma comparisons (ie, Y-3L vs coma), 10 paired comparisons (Y-3L vs Y-3L) and 10 kaizen tasks (preference paths). In addition to comparing evidence by task (aim 2), the analysis plan includes the estimation of main-effects conditional logit models to create a Y-3L value set on an 'experience scale' where positive (negative) experiences have positive (negative) values (0 is 'being in a coma' and 1 is full health).
The institutional review board (IRB) (Advarra) determined that this project (Pro00072276) is exempt from IRB oversight based on DHHS 45 CFR 46.104(d)(2) and is not subject to requirements for continuing review. The results will be prepared for publication in peer-reviewed journals and presented at scientific meetings. The data and code will be made available on reasonable request.
十年前，首次对 EQ-5D-Y-3L（Y-3L）进行全国估值研究时，涉及一项离散选择实验（DCE），该实验要求 4155 名美国成年受访者完成 40 对配对比较，在两个垂死的孩子之间做出选择。与在垂死的孩子之间进行选择不同，本协议中的受访者被问及“昏迷”是比经历“健康问题”（即体验量表）更好还是更差，以及他们将如何缓解健康问题（即 Kaizen 任务）。我们的目的是比较配对比较和 Kaizen 任务的偏好证据，并对体验量表上的 Y-3L 进行 DCE 估值。
根据本协议，我们将进行一项在线调查，该调查将在一周内从 600 名美国成年受访者那里收集有关 10 岁儿童健康状况的偏好证据。在所有情况下，每个孩子都将被描述为处于“昏迷”或患有“健康问题”，即五个三级属性（Y-3L）。在这种 DCE 中，每个受访者将被随机分配到四个 D-有效块之一，其中包括五个昏迷比较（即 Y-3L 与昏迷），10 对比较（Y-3L 与 Y-3L）和 10 个 Kaizen 任务（偏好路径）。除了按任务比较证据（目标 2）外，分析计划还包括主效应条件逻辑模型的估计，以在“体验量表”上创建 Y-3L 值集，其中正（负）体验具有正（负）值（0 是“昏迷”，1 是完全健康）。
机构审查委员会（IRB）（Advarra）根据 DHHS 45 CFR 46.104(d)(2)确定该项目（Pro00072276）免于 IRB 监督，且不受持续审查要求的约束。研究结果将准备在同行评议的期刊上发表，并在科学会议上展示。将根据合理要求提供数据和代码。
