CRISPR：历史与未来展望。
CRISPR: History and perspectives to the future.
机构信息
Department of Molecular Oncology, Cancer Research Institute, Biomedical Research Center, University Science Park for Biomedicine, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Department of Cell and Molecular Biology of Drugs Faculty of Pharmacy, Comenius University, Odbojarov 10, 83232 Bratislava, Slovakia.
出版信息
Biomed Pharmacother. 2021 Sep;141:111917. doi: 10.1016/j.biopha.2021.111917. Epub 2021 Jul 16.
This review summarizes the information about the history and future of the CRISPR/Cas9 method. Genome editing can be perceived as a group of technologies that allow scientists to change the DNA of an organism. These technologies involve the deletion, insertion, or modification of the genome at a specific site in a DNA sequence. Gene therapy in humans has a perspective to be used to eliminate the gene responsible for a particular genetic disorder. The review focuses on the key elements of this promising method and the possibility of its application in the treatment of cancer and genetic diseases.
这篇综述总结了 CRISPR/Cas9 方法的历史和未来信息。基因组编辑可以被视为一组技术，使科学家能够改变生物体的 DNA。这些技术涉及在 DNA 序列的特定位置删除、插入或修饰基因组。人类基因治疗有希望用于消除导致特定遗传疾病的基因。该综述重点介绍了这种有前途的方法的关键要素及其在癌症和遗传疾病治疗中的应用可能性。
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