Matinvafa Mohammad Ali, Makani Shadi, Parsasharif Negin, Zahed Mohammad Ali, Movahed Elaheh, Ghiasvand Saeedeh
Department of Biotechnology & Environment, Faculty of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
Faculty of Biological Sciences, Kharazmi University, Tehran, 14911 - 15719 Iran.
3 Biotech. 2023 Nov;13(11):383. doi: 10.1007/s13205-023-03786-7. Epub 2023 Oct 31.
The CRISPR-Cas system's applications in biotechnology offer a promising avenue for addressing pressing global challenges, such as climate change, environmental pollution, the energy crisis, and the food crisis, thereby advancing sustainability. The ever-growing demand for food due to the projected population of around 9.6 billion by 2050 requires innovation in agriculture. CRISPR-Cas technology emerges as a powerful solution, enhancing crop varieties, optimizing yields, and improving resilience to stressors. It offers multiple gene editing, base editing, and prime editing, surpassing conventional methods. CRISPR-Cas introduces disease and herbicide resistance, high-yielding, drought-tolerant, and water-efficient crops to address rising water utilization and to improve the efficiency of agricultural practices which promise food sustainability and revolutionize agriculture for the benefit of future generations. The application of CRISPR-Cas technology extends beyond agriculture to address environmental challenges. With the adverse impacts of climate change and pollution endangering ecosystems, there is a growing need for sustainable solutions. The technology's potential in carbon capture and reduction through bio-sequestration is a pivotal strategy for combating climate change. Genomic advancements allow for the development of genetically modified organisms, optimizing biofuel and biomaterial production, and contributing to a renewable and sustainable energy future. This study reviews the multifaceted applications of CRISPR-Cas technology in the agricultural and environmental fields and emphasizes its potential to secure a sustainable future.
CRISPR-Cas系统在生物技术中的应用为应对诸如气候变化、环境污染、能源危机和粮食危机等紧迫的全球挑战提供了一条充满希望的途径,从而推动可持续发展。到2050年预计全球人口约96亿,由此对粮食的需求不断增长,这就需要农业创新。CRISPR-Cas技术应运而生,成为一种强大的解决方案,可改良作物品种、优化产量并提高对压力源的耐受性。它提供多种基因编辑、碱基编辑和引导编辑,超越了传统方法。CRISPR-Cas引入了抗病和抗除草剂、高产、耐旱和节水的作物品种,以应对不断增长的水资源利用需求,并提高农业生产效率,有望实现粮食可持续性,为子孙后代彻底变革农业。CRISPR-Cas技术的应用不仅限于农业领域,还可用于应对环境挑战。随着气候变化和污染的不利影响危及生态系统,对可持续解决方案的需求日益增长。该技术通过生物固存实现碳捕获和减排的潜力是应对气候变化的关键策略。基因组学的进步使得转基因生物的开发成为可能,优化生物燃料和生物材料的生产,并为可再生和可持续的能源未来做出贡献。本研究回顾了CRISPR-Cas技术在农业和环境领域的多方面应用,并强调了其确保可持续未来的潜力。