应用反射共聚焦显微镜预测咖啡斑的治疗效果。
Use of Reflectance Confocal Microscopy to Predict Treatment Efficacy in Café Au Lait Macules.
机构信息
Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Dermatol Surg. 2021 Mar 1;47(3):e71-e74. doi: 10.1097/DSS.0000000000002797.
BACKGROUND
Multiple lasers have been used for the treatment of café au lait macules (CALMs) with various results. Objective tools to predict therapeutic efficacy of CALMs treatment is lacking.
OBJECTIVE
To determine whether reflectance confocal microscopy (RCM) characteristics correlate with CALMs response to laser treatment.
MATERIALS AND METHODS
All CAMLs underwent RCM examination of length and density of dermal papillae followed by 3 sessions of Q-switched alexandrite laser (QSAL). A visual analog scale was used to assess clinical treatment efficacy.
RESULTS
Forty-three patients were included, 22 had CALMs with irregular borders and 21 with smooth borders. Café au lait macules with irregular border had shorter rete pegs and less papillae (p < .05) on RCM compared with smooth border CAMLs and responded better to QSAL treatment (2.32 vs 1.10).
CONCLUSION
Reflectance confocal microscopy measurement of length and density of papillae were inversely correlated with treatment response. Reflectance confocal microscopy may be a useful tool to predict CALMs response to laser treatment.
背景
已有多种激光应用于治疗咖啡斑（CALMs），但效果不一。目前缺乏用于预测 CALMs 治疗效果的客观工具。
目的
确定反射共聚焦显微镜（RCM）特征是否与激光治疗 CALMs 的反应相关。
材料与方法
所有 CALMs 均行 RCM 检查，测量真皮乳头的长度和密度，随后行 3 次 Q-开关亚历山大激光（QSAL）治疗。采用视觉模拟评分评估临床治疗效果。
结果
共纳入 43 例患者，其中 22 例 CALMs 边界不规则，21 例边界规则。与边界规则的 CALMs 相比，边界不规则的 CALMs 在 RCM 下具有更短的乳突和更少的乳头（p<0.05），且对 QSAL 治疗的反应更好（2.32 比 1.10）。
结论
RCM 测量的乳头长度和密度与治疗反应呈负相关。反射共聚焦显微镜可能是预测 CALMs 对激光治疗反应的有用工具。
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