de Oliveira Marina Martins, Pereira Carine Rodrigues, de Oliveira Izabela Regina Cardoso, Godfroid Jacques, Lage Andrey Pereira, Dorneles Elaine Maria Seles
Departamento de Medicina Veterinária, Faculdade de Zootecnia e Medicina Veterinária, Universidade Federal de Lavras - UFLA, Lavras, Brazil.
Departamento de Estatística, Instituto de Ciências Exatas e Tecnológicas, Universidade Federal de Lavras - UFLA, Lavras, Brazil.
Transbound Emerg Dis. 2022 Jul;69(4):e32-e51. doi: 10.1111/tbed.14259. Epub 2021 Aug 14.
This systematic review and meta-analysis aimed to recalculate the efficacy of Brucella abortus S19 and RB51 vaccine strains and discuss the main variables associated with controlled trials to evaluate bovine brucellosis vaccine efficacy (VE). The most commonly used vaccine strain was S19, at a dose of 10 colony forming units (CFU), followed by RB51 at 10 CFU. The most commonly used challenge strain was B. abortus 2308, at a dose of 10 CFU, by the intraconjunctival route. Regarding the meta-analysis, trials were grouped according to the vaccine strain and dose to recalculate protection against abortion (four groups) or infection (five groups) using pooled risk ratio (RR) and VE. Regarding protection against abortion (n = 15 trials), the S19 vaccine at 10 CFU exhibited the highest protection rate (RR = 0.25, 95% confidence interval (CI) : 0.12-0.52; VE = 75.09%, 95% CI: 48.08-88.05), followed by RB51 at 10 CFU (RR = 0.31, 95% CI: 0.16-0.61; VE = 69.25%, 95% CI: 39.48-84.38). Regarding protection against infection (n = 23 trials), only two subgroups exhibited significant protection: S19 at 10 CFU (RR = 0.28, 95% CI: 0.14-0.55; VE = 72.03%, 95% CI: 57.70- 81.50) and RB51 at 10 CFU (RR = 0.43, 95% CI: 0.22-0.84; VE = 57.05%, 95% CI: 30.90-73.30). In conclusion, our results suggest that a dose of 10 CFU for S19 and 10 CFU for RB51 are the most suitable for the prevention of abortion and infection caused by B. abortus.
本系统评价和荟萃分析旨在重新计算流产布鲁氏菌S19和RB51疫苗株的效力，并讨论与评估牛布鲁氏菌病疫苗效力（VE）的对照试验相关的主要变量。最常用的疫苗株是S19，剂量为10个菌落形成单位（CFU），其次是RB51，剂量为10 CFU。最常用的攻毒株是流产布鲁氏菌2308，剂量为10 CFU，通过结膜内途径接种。关于荟萃分析，根据疫苗株和剂量对试验进行分组，使用合并风险比（RR）和VE重新计算预防流产（四组）或感染（五组）的效果。关于预防流产（n = 15项试验），10 CFU的S19疫苗显示出最高的保护率（RR = 0.25，95%置信区间（CI）：0.12 - 0.52；VE = 75.09%，95% CI：48.08 - 88.05），其次是10 CFU的RB51（RR = 0.31，95% CI：0.16 - 0.61；VE = 69.25%，95% CI：39.48 - 84.38）。关于预防感染（n = 23项试验），只有两个亚组显示出显著的保护作用：10 CFU的S19（RR = 0.28，95% CI：0.14 - 0.55；VE = 72.03%，95% CI：57.70 - 81.50）和10 CFU的RB51（RR = 0.43，95% CI：0.22 - 0.84；VE = 57.05%，95% CI：30.9
