Dawood Ali Sobhy, Elrashedy Alyaa, Nayel Mohamed, Salama Akram, Guo Aizhen, Zhao Gang, Algharib Samah Attia, Zaghawa Ahmed, Zubair Muhammed, Elsify Ahmed, Mousa Walid, Luo Wanhe
Engineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science and Technology, Tarim University, Alar, Xinjiang, China.
The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Front Vet Sci. 2023 Oct 9;10:1255239. doi: 10.3389/fvets.2023.1255239. eCollection 2023.
Brucellosis is considered one of the most hazardous zoonotic diseases all over the world. It causes formidable economic losses in developed and developing countries. Despite the significant attempts to get rid of pathogens in many parts of the world, the disease continues to spread widely. Recently, many attempts proved to be effective for the prevention and control of highly contagious bovine brucellosis, which could be followed by others to achieve a prosperous future without rampant pathogens. In this study, the updated view for worldwide distribution, possible predisposing factors for emerging pathogens, immune response and different types of vaccines, genomics and proteomics approaches incorporated recently in the field of brucellosis, and future perspectives for prevention and control of bovine brucellosis have been discussed comprehensively. So, the current study will be used as a guide for researchers in planning their future work, which will pave the way for a new world without these highly contagious pathogens that have been infecting and threatening the health of humans and terrestrial animals.
布鲁氏菌病被认为是全球最危险的人畜共患病之一。它在发达国家和发展中国家都造成了巨大的经济损失。尽管世界许多地区都在大力尝试清除病原体，但这种疾病仍在广泛传播。最近，许多尝试被证明对预防和控制高度传染性的牛布鲁氏菌病有效，其他地区可以效仿，以实现一个没有猖獗病原体的繁荣未来。在本研究中，全面讨论了布鲁氏菌病在全球的分布现状、新发病原体可能的诱发因素、免疫反应、不同类型的疫苗、最近在布鲁氏菌病领域采用的基因组学和蛋白质组学方法，以及牛布鲁氏菌病预防和控制的未来展望。因此，本研究将为研究人员规划未来工作提供指导，为一个没有这些一直在感染和威胁人类及陆生动物健康的高度传染性病原体的新世界铺平道路。
