State Key Laboratory of Chemical Oncogenomics, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Shenzhen Key Laboratory of Health Science and Technology, Institute of Biopharmaceutical and Health, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Molecules. 2024 May 13;29(10):2291. doi: 10.3390/molecules29102291.
, as a globally prevalent evergreen tree, contains a wealth of bioactive components that play a crucial role in the pharmaceutical field. extracts, defined as a collection of one or more bioactive compounds extracted from the genus spp., have become a significant focus of modern cancer treatment research. This review article aims to delve into the scientific background of extracts and their considerable value in pharmaceutical research. It meticulously sifts through and compares various advanced extraction techniques such as supercritical extraction, ultrasound extraction, microwave-assisted extraction, solid-phase extraction, high-pressure pulsed electric field extraction, and enzymatic extraction, assessing each technology's advantages and limitations across dimensions such as extraction efficiency, extraction purity, economic cost, operational time, and environmental impact, with comprehensive analysis results presented in table form. In the area of drug formulation design, this paper systematically discusses the development strategies for solid, liquid, and semi-solid dosage forms based on the unique physicochemical properties of extracts, their intended medical uses, and specific release characteristics, delving deeply into the selection of excipients and the critical technical issues in the drug preparation process. Moreover, the article looks forward to the potential directions of extracts in future research and medical applications, emphasizing the urgency and importance of continuously optimizing extraction methods and formulation design to enhance treatment efficacy, reduce production costs, and decrease environmental burdens. It provides a comprehensive set of preparation techniques and formulation optimization schemes for researchers in cancer treatment and other medical fields, promoting the application and development of extracts in pharmaceutical sciences.
, 作为一种全球普遍存在的常绿乔木,含有丰富的生物活性成分,在制药领域发挥着重要作用。 提取物被定义为从 属的一种或多种生物活性化合物的混合物,已成为现代癌症治疗研究的一个重要焦点。本文旨在深入探讨 提取物的科学背景及其在药物研究方面的巨大价值。本文精心筛选和比较了各种先进的提取技术,如超临界提取、超声提取、微波辅助提取、固相提取、高压脉冲电场提取和酶提取,从提取效率、提取纯度、经济成本、操作时间和环境影响等方面评估了每种技术的优缺点,并以表格形式呈现全面的分析结果。在药物制剂设计领域,本文系统地讨论了基于 提取物独特的物理化学性质、预期的医疗用途和特定的释放特性的固体、液体和半固体剂型的开发策略,深入探讨了赋形剂的选择和药物制备过程中的关键技术问题。此外,本文还展望了 提取物在未来研究和医学应用中的潜在方向,强调不断优化提取方法和制剂设计以提高治疗效果、降低生产成本和减少环境负担的紧迫性和重要性。它为癌症治疗和其他医学领域的研究人员提供了一套全面的制剂技术和配方优化方案,促进了 提取物在药物科学中的应用和发展。