Jîjie Alex-Robert, Iliescu Dan, Sbârcea Laura, Boru Casiana, Pătrașcu Dalia, Iftode Oana Andrada, Minda Ionela-Daliana, Avram Ștefana, Trandafirescu Cristina-Maria, Dehelean Cristina Adriana, Moacă Elena-Alina
University Clinic of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.
Research Centre for Pharmaco-Toxicological Evaluation, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.
Plants (Basel). 2025 May 11;14(10):1439. doi: 10.3390/plants14101439.
The genus comprises a unique group of gymnosperms known for their botanical longevity, cultural significance, and exceptional pharmacological potential. This review explores the multifaceted profile of species, with a focus on their morphological traits, phytochemical composition, traditional uses, and therapeutic applications. Particular attention is given to taxanes, especially paclitaxel, which have revolutionized cancer treatment through microtubule-stabilizing mechanisms. In addition to well-established uses of the bark and leaves, the review synthesizes emerging research on the aril, a non-toxic and antioxidant-rich plant part, suggesting novel biomedical applications. By integrating ethnobotanical knowledge with contemporary pharmacological insights, this work underscores the enduring relevance of in traditional medicine while emphasizing its evolving role in modern drug discovery. The findings advocate for intensified interdisciplinary research and sustainable exploitation strategies to fully harness the genus's therapeutic potential without compromising biodiversity.
该属包含一组独特的裸子植物,以其植物寿命长、文化意义重大和卓越的药理潜力而闻名。本综述探讨了该属物种的多方面特征,重点关注其形态特征、植物化学成分、传统用途和治疗应用。特别关注紫杉烷类,尤其是紫杉醇,它们通过微管稳定机制彻底改变了癌症治疗。除了树皮和树叶的既定用途外,本综述还综合了关于假种皮(一种无毒且富含抗氧化剂的植物部分)的新兴研究,提出了新的生物医学应用。通过将民族植物学知识与当代药理学见解相结合,这项工作强调了该属在传统医学中的持久相关性,同时强调了其在现代药物发现中不断演变的作用。研究结果主张加强跨学科研究和可持续开发策略,以在不损害生物多样性的情况下充分利用该属的治疗潜力。