Faculty of Medicine, Department of Modern Sciences and Technologies, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Adv Exp Med Biol. 2021;1291:41-53. doi: 10.1007/978-3-030-56153-6_3.
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which involves an auto-immune mechanism that leads to perivascular demyelination. The role of nuclear factor-kappa B (NF-κB) signaling pathway in the pathogenesis of MS has been suggested by genome-wide association studies. Therefore, strategies targeting this pathway could be potentially beneficial. Curcumin is the active component of turmeric and a phenolic phytochemical. This phytochemical has anti-inflammatory properties and has been shown by multiple studies to downregulate NF-κB and its downstream gene targets including cyclooxygenase-2, tumor necrosis factor-α, interleukin-1, and interleukin-6. This review discusses the modulatory effects of curcumin on the NF-κB signaling pathway and its downstream effectors, and the therapeutic implications of this modulation on MS.
多发性硬化症（MS）是一种中枢神经系统的慢性炎症性疾病，涉及自身免疫机制，导致血管周围脱髓鞘。全基因组关联研究提示核因子-κB（NF-κB）信号通路在 MS 的发病机制中的作用。因此，靶向该通路的策略可能具有潜在的益处。姜黄素是姜黄的活性成分，也是一种酚类植物化学物质。这种植物化学物质具有抗炎特性，多项研究表明它可以下调 NF-κB 及其下游基因靶点，包括环氧化酶-2、肿瘤坏死因子-α、白细胞介素-1 和白细胞介素-6。本文讨论了姜黄素对 NF-κB 信号通路及其下游效应物的调节作用，以及这种调节对 MS 的治疗意义。
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