Arneth Borros
Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg (UKGM), Justus Liebig University Giessen, Feulgenstr. 12, 35392 Giessen, Germany.
Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg (UKGM), Philipps University Marburg, Baldinger Str., 35043 Marburg, Germany.
Int J Mol Sci. 2024 Nov 30;25(23):12906. doi: 10.3390/ijms252312906.
Multiple sclerosis (MS) is a condition that is characterized by damage to the central nervous system (CNS) that causes patients to experience cognitive and physical difficulties. Although the disease has a complex etiology that involves genetic and environmental factors, little is known about the role of genes and gene loci in its development. Aims: This study aimed to investigate the effects of genes and gene loci on the immune system during the development of MS. We aimed to identify the main genes and gene loci that play roles in MS pathogenesis and the implications for the future development of clinical treatment approaches. A systematic review of articles published over the last decade was conducted. This review focused on studies about the genetic and epigenetic mechanisms underlying MS onset and progression. Genome-wide association studies (GWASs) as well as papers describing the role of the immune system in disease development were prioritized. Key genetic loci and immune system-related genes, such as HLA class II genes, are associated with MS susceptibility. Studies have also shown that epigenetic modifications, such as DNA methylation, influence disease progression via the immune system.
多发性硬化症（MS）是一种以中枢神经系统（CNS）受损为特征的疾病，会导致患者出现认知和身体方面的困难。尽管该疾病的病因复杂，涉及遗传和环境因素，但对于基因和基因座在其发展过程中的作用却知之甚少。目的：本研究旨在调查基因和基因座在MS发展过程中对免疫系统的影响。我们旨在确定在MS发病机制中起作用的主要基因和基因座，以及对未来临床治疗方法发展的影响。对过去十年发表的文章进行了系统综述。该综述聚焦于MS发病和进展背后的遗传和表观遗传机制的研究。全基因组关联研究（GWAS）以及描述免疫系统在疾病发展中作用的论文被列为优先研究对象。关键基因座和与免疫系统相关的基因，如HLA II类基因，与MS易感性相关。研究还表明，表观遗传修饰，如DNA甲基化，通过免疫系统影响疾病进展。
